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A Phase 2 Evaluation of TRC105 In Combination With Bevacizumab in Patients With Glioblastoma — 105GM201  

Glioblastoma Clinical Trial

Official title:
A Phase 2 Evaluation of TRC105 In Combination With Bevacizumab for the Treatment Of Recurrent or Progressive Glioblastoma That Has Progressed on Bevacizumab

Clinical Trial Summary

The purpose of this study is to evaluate the safety and efficacy of TRC105 in patients with recurrent or progressive glioblastoma after prior antiangiogenic therapy (including anti-VEGF therapy)

Clinical Trial Description

Angiogenesis plays a central role in the progression of solid cancer. TRC105 is an antibody to CD105, an important non-VEGF angiogenic target on proliferating endothelial cells. TRC105 inhibits angiogenesis, tumor growth and metastases in preclinical models. TRC105 has been well tolerated in patients with glioblastoma (GBM) as a single agent. The combination of TRC105 in combination with bevacizumab has demonstrated activity in bevacizumab refractory cancer patients. We hypothesize that TRC105 when administered with bevacizumab will have activity in GBM patients who progress on bevacizumab. By targeting a non-VEGF pathway, TRC105 has the potential to complement VEGF inhibition by bevacizumab, which could represent a major advance in GBM therapy. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT01564914
Study type Interventional
Source Tracon Pharmaceuticals Inc.
Contact
Status Completed
Phase Phase 2
Start date May 2012
Completion date June 2015
View Details
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