Glioblastoma Multiforme Clinical Trial
Official title:
Phase I/II Study of Fractionated CyberKnife Stereotactic Radiosurgery for High Grade Gliomas in Elderly Patients With Poor Performance Status
Conventional radiation for 6 weeks is not well tolerated by the elderly. Shorter courses
(over 3-5 weeks) of radiation have been shown to be equivalent in outcome the elderly-
particularly in patients who are generally in poor performance status (KPS<70). Fractionated
Cyberknife Radiosurgery can deliver equivalent doses in 5 treatments providing the same
tumor control in a much shorter and tolerable schedule improving their quality of their
short life.
To assess the tolerability of Cyberknife Radiosurgery for High Grade Gliomas in Elderly with
poor performance status.
Secondary:
Assessment of local control rate, progression free survival, overall survival, quality of
life and toxicity and steroid dependence in this population with this regime.
Conventional radiation for 6 weeks is not well tolerated by the elderly. Shorter courses (over 3-5 weeks) of radiation have been shown to be equivalent in outcome the elderly- particularly in patients who are generally in poor performance status (KPS<70). Fractionated Cyberknife Radiosurgery can deliver equivalent doses in 5 treatments providing the same tumor control in a much shorter and tolerable schedule improving their quality of their short life. ;
Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
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