Use of Gallium-68 HA-DOTATATE PET/CT in Giant Cell Arteritis (GCA)

Status Completed

Clinical Trial Summary

The aim of this study is to compare the use of FDG PET/CT to Ga-68 HA-DOTATATE (abbreviated DOTATATE) PET/CT in patients with active giant cell arteritis (GCA) started on prednisone to understand if DOTATATE can identify more areas of active blood vessel inflammation than FDG.

Clinical Trial Description

The aim of this study is to prospectively evaluate the potential use of 68-Ga HA-DOTATATE PET/CT for detecting medium-large vessel inflammation in a small number of GCA patients with active disease, as compared to FDG PET/CT, and to understand if DOTATATE uptake correlates with disease activity. Fifteen patients with active GCA (either newly-diagnosed or recently relapsed disease) who are receiving glucocorticoids will be enrolled. Participants will undergo baseline FDG PET/CT and baseline DOTATATE PET/CT scan. Tracer uptake will be described in 8 major vascular territories. DOTATATE PET/CT will be repeated again in 6 months, and tracer uptake will be correlated to clinical disease activity, and medication use. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT03812302
Study type	Interventional
Source	University of Alberta
Contact
Status	Completed
Phase	Phase 2
Start date	September 9, 2019
Completion date	September 30, 2023

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