Effect of HSV-2 Suppressive Therapy on Sexual Behavior

Status Terminated

Clinical Trial Summary

The purpose of this study is to determine what effect suppressive therapy has on sexual behavior and quality of life among persons with genital herpes (HSV) who have multiple sex partners. Study terminated; investigator relocated and study funding ended. Results were never analyzed because data were not collected.

Clinical Trial Description

We plan to conduct a randomized controlled trial of chronic suppressive acyclovir, 400 mg orally twice daily (standard dose) versus episodic acyclovir for treatment of genital herpes recurrences. We will enroll 500 HSV-2 seropositive single persons (250 per arm), stratified by gender and history of symptomatic genital herpes, and prospectively follow them for 1 year to assess sexual behavior, adherence to therapy, and herpes-related quality of life. These outcomes will be measured by self-report in a confidential, computer-based assessment. We plan to use data from this trial to model the effect that increasing the proportion of sexually-active HSV-2 infected persons taking suppressive therapy will have on population-level incidence and prevalence of HSV-2. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT00495716
Study type	Interventional
Source	University of Washington
Contact
Status	Terminated
Phase	Phase 4
Start date	January 2008
Completion date	June 2010

View Details

See also
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