Genetics Clinical Trial
Official title:
A Genome-Wide Scan For Quantitative Trait Loci of Serum Bilirubin - A Framingham Study
Studies have shown that there is a significant association between serum bilirubin concentrations and risk of coronary artery disease (CAD). So far, no linkage analysis in humans between serum bilirubin and DNA markers has been reported. The purpose of this protocol is to identify chromosome regions that contain quantitative trait loci (QTL) involved in serum bilirubin metabolism and bilirubin concentration. In the Framingham Study, a 10cM genome scan (about 400 markers) has been conducted in more than three hundred families. Serum bilirubin was measured in the first and second exams of the Framingham Offspring. These data provide us the opportunity to undertake linkage analyses to map QTL of serum bilirubin.
Many studies showed that there is a significant relationship between serum bilirubin levels and risk of coronary artery disease (CAD). We carried out a genome-wide scan for quantitative trait loci of serum bilirubin through the 330 extended Framingham families and found significant evidence of linkage of serum bilirubin to chromosome 2q telomere where an important candidate gene, Uridine diphosphate glycosyltransferase 1 gene (UGT1A1), resides. The purposes of this protocol are to confirm linkage between serum bilirubin and UGT1A1, mathematical modeling and association studies between the genotypes of UGT1A1 and CAD. ;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT03572322 -
Genetics Tests : How to Improve Management Within Two Medical Specialities
|
||
| Recruiting |
NCT05394363 -
Generation Victoria Cohort 2020s: A Statewide Longitudinal Cohort Study of Victorian Children and Their Parents
|
||
| Recruiting |
NCT02671253 -
Myomectomies:Tumor Characteristics and Clinical Implications
|
N/A | |
| Completed |
NCT01317134 -
Endothelial Function in Patients With Pulmonary Arterial Hypertension
|
N/A | |
| Terminated |
NCT02566161 -
Parental Irradiation of Ukrainian Cleanup Workers and Evacuees and Germline Mutations in Their Offspring (Trio Study)
|
||
| Completed |
NCT03973060 -
Effectiveness of Muscular Work and Genetic Variants in Strength Gain of Ischiofemoral and Quadriceps
|
N/A | |
| Terminated |
NCT01375556 -
Genetics of the Acute Response to Alcohol in Social Drinkers
|
Phase 1 | |
| Recruiting |
NCT00418912 -
Family Study in Schizophrenia
|
N/A | |
| Completed |
NCT03446079 -
Relationship of Skin Related SNP to Topical Skin Care Product
|
N/A | |
| Recruiting |
NCT04024631 -
Phenotyping Genetic Risk for Type 2 Diabetes
|
N/A | |
| Completed |
NCT00339924 -
Physicians' Understanding of Human Genetic Variation
|
||
| Not yet recruiting |
NCT05851209 -
Biomarkers and Mechanisms of Disease Progression and Outcome of Aortic Stenosis in Humans
|
||
| Completed |
NCT03301519 -
Genetics of Beta Cell Failure in Mexican Americans
|
||
| Completed |
NCT01294345 -
Personalized Genomic Research
|
||
| Recruiting |
NCT03650829 -
IVF Offspring Born in Guangzhou
|
||
| Recruiting |
NCT06239077 -
Identifai Genetics Analytic Validity Study - Compound Heterozygosity and Samples Collection
|
N/A | |
| Completed |
NCT02225171 -
Physicians' Experiences With and Attitudes Toward Non-Medical Sex Selection Through Preimplantation Genetic Diagnosis
|
||
| Not yet recruiting |
NCT04038281 -
Genetics of Bitter and Fat Taste
|
||
| Completed |
NCT03572205 -
Fatty Acid Desaturase Gene Locus Interactions With Diet (FADSDIET2)
|
N/A | |
| Recruiting |
NCT03221322 -
How do Super Lean Subjects Keep Resistant to Body Weight Gain?
|