Genetic Testing Clinical Trial
Official title:
Evaluation of the Implementation of Expanded Carrier Screening Before Pregnancy in Hong Kong
The objectives are to:
1. Assess patient's views and preferences in receiving expanded carrier screening
2. Perform qualitative study on post testing counselling on screen positive individuals
and at risk couples
This study is to recruit 50 couples for Expanded carrier screening at Prepregnancy Checkup
Clinic at the Family Planning Association.
Saliva swabs are collected from couples for Hereditary Disease DNA screening test by DrGene.
Blood samples are taken by venipuncture of women for Fragile X carrier screening by Prenatal
Diagnostic Laboratory, Tsan Yuk Hospital.
A pre-test self-administered Questionnaire 1 will be administered to couples to assess their
knowledge, views and preferences in receiving expanded carrier screening. This include
collection of basic demographic information, answers to questions on basic principles of
expanded carrier testing, reasons of having or declining the test, choice of having
concurrent or sequential screening, factors affecting their choices, anxiety level of the
patient is assessed by state-trait anxiety inventory. Their willingness to pay for the test
is also assessed.
The test results will be available to couples in 6 week's time. A post-test
self-administered questionnaire 2 will be administered to couples on receiving the test
results at the clinic. These include assessment of anxiety level, any decision regret,
outcome of test and resulting action.
The couples with a screen positive result will be referred to Queen Mary Hospital for a
joint counselling by clinical geneticist and gynaecologist. This counselling/consultation
shall be audiotaped or videotaped. The interviews will be transcribed verbatim. The data
will be explored for themes and issues identified.
Statistics Questionnaire survey data shall be entered into SPSS. Descriptive statistics will
be used to compare responses and choices of participants.
;
Observational Model: Cohort, Time Perspective: Prospective
Status | Clinical Trial | Phase | |
---|---|---|---|
Completed |
NCT03988504 -
Impact of Predictive Genetic Testing
|
||
Not yet recruiting |
NCT05159011 -
Access to Genetic Information Leveraging Innovative Technology (AGILITY)
|
N/A | |
Recruiting |
NCT02691689 -
Genes Associated With Development of Pulmonary Arterial Hypertension in Patients With Congenital Shunt Lesions
|
N/A | |
Completed |
NCT04704193 -
Development and Implementation of Electronic Decision Aids for Genetic Testing in Inherited Cancer Syndromes
|
N/A | |
Completed |
NCT05545254 -
Health-promoting Lifestyle in a Genetic Counseling Clinic
|
||
Recruiting |
NCT05348564 -
Comparing Direct vs Indirect Methods for Cascade Screening
|
N/A | |
Recruiting |
NCT05360095 -
Comparing Game Facilitated Interactivity to Genetic Counseling for Prenatal Screening Education
|
N/A | |
Active, not recruiting |
NCT03869515 -
Genetic Causes and Clinical Features of Childhood Interstitial Lung Diseases in China
|
||
Recruiting |
NCT04856696 -
Clinical Application of Non-invasive PGT-A
|
N/A | |
Recruiting |
NCT04481061 -
Engaging Adolescents in Decisions About Return of Genomic Research Results
|
N/A | |
Recruiting |
NCT04656028 -
Genetic Testing and Motivational Counseling for FH
|
N/A | |
Recruiting |
NCT03396341 -
Responses to Genetic Risk Modifier Testing Among Women With BRCA1/2 Mutations
|
||
Active, not recruiting |
NCT04245176 -
Genetic Testing for All Breast Cancer Patients (GET FACTS)
|
N/A | |
Active, not recruiting |
NCT02665195 -
Prospective Registry of Multiplex Testing (PROMPT)
|
||
Recruiting |
NCT06073626 -
Personalized Oncology Promoting Equity for Black Lives
|
N/A | |
Recruiting |
NCT05225428 -
Video Education With Result Dependent dIsclosure
|
N/A | |
Active, not recruiting |
NCT05265624 -
The Moran AMD Genetic Testing Assessment Study
|
Phase 2 | |
Withdrawn |
NCT01663584 -
Multi-disease Carrier Screening Test Validation
|
N/A | |
Recruiting |
NCT05055700 -
Impact of a Mobile App on Pregnant Women's Prenatal Genetic Testing Decision-making
|
N/A |