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NCT04369014 Clinical Trial

Effect of Etomidate and Propofol on Electroencephalography

General Anesthesia Clinical Trial

— CHAPE  

Official title:
Characteristic Changes During Anesthesia With Etomidate and Propofol

Clinical Trial Details — Status: Recruiting

Administrative data
NCT number NCT04369014
Other study ID # XJH-A-20200330
Secondary ID
Status Recruiting
Phase N/A
First received
Last updated
Start date February 28, 2022
Est. completion date February 28, 2023

Study information
Verified date May 2022
Source Air Force Military Medical University, China
Contact Zhihong Lu
Phone +862984775343
Email deerlu23@163.com
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

Electroencephalography (EEG) monitoring reflect the brain electro-activity. Different anesthetics may show different changes in EEG during anesthesia. Etomidate and propofol are widely used for general anesthesia. The characteristic changes of these two anesthetics may be different.

Recruitment information / eligibility
Status Recruiting
Enrollment 68
Est. completion date February 28, 2023
Est. primary completion date December 30, 2022
Accepts healthy volunteers No
Gender All
Age group 18 Years and older
Eligibility Inclusion Criteria: - Patients scheduled for surgery under general anesthesia - Patients provided written informed consent Exclusion Criteria: - Patients with history of neurological or psychiatric diseases - Patients younger than 18 years old - Patients scheduled for surgery involved head - Patients with pregnancy or planned for breeding

Study Design

Related Conditions & MeSH terms

Intervention

Drug:
• etomidate anesthesia
etomidate is used for induction and maintenance of general anesthesia
• propofol anesthesia
propofol is used for induction and maintenance of general anesthesia

Locations
Country Name City State
China Xijing hospital Xi'an Shaanxi

Sponsors (1)
Lead Sponsor Collaborator
Air Force Military Medical University, China

Country where clinical trial is conducted

China, 

Outcome
Type Measure Description Time frame Safety issue
Primary delta wave deficiency during anesthesia from anesthesia induction to extubation of the endotracheal tube, on an average of 2.5 hours
Secondary spindle wave deficiency during anesthesia from anesthesia induction to extubation of the endotracheal tube, on an average of 2.5 hours
Secondary burst suppression during anesthesia from anesthesia induction to extubation of the endotracheal tube, on an average of 2.5 hours
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