Clinical Trials Logo
  1. Home
  2. General Anesthesia
  3. NCT02000973
  4. Details
NCT02000973 Clinical Trial

Effects of Epidural Local Anesthetics on Propofol Induction

General Anesthesia Clinical Trial

Official title:
Effects of Thoracic Epidural Anesthesia With Different Local Anesthetics on Propofol Induction

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT02000973
Other study ID # 20131012
Secondary ID
Status Completed
Phase Phase 4
First received November 22, 2013
Last updated April 20, 2014
Start date November 2013
Est. completion date March 2014

Study information
Verified date April 2014
Source First Hospital of China Medical University
Contact n/a
Is FDA regulated No
Health authority China: Ethics Committee
Study type Interventional

Clinical Trial Summary

The investigators designed a prospective, randomized, placebo-controlled study to determine whether thoracic epidural anesthesia(TEA) with different local anesthetics has different influences on the propofol dose during induction.

Recruitment information / eligibility
Status Completed
Enrollment 80
Est. completion date March 2014
Est. primary completion date January 2014
Accepts healthy volunteers No
Gender Both
Age group 45 Years to 65 Years
Eligibility Inclusion Criteria:

Surgery for thoracotomies, BMI: 18-25 Kg/m2, American Society of Anesthesiologists(ASA) classification I or II.

Exclusion Criteria:

liver or kidney disease, alcohol dependence, take sedative recently, contraindications for epidural anesthesia.

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Outcomes Assessor), Primary Purpose: Treatment

Related Conditions & MeSH terms

Intervention

Drug:
• Lidocaine
General anesthesia combined with thoracic epidural 1% lidocaine
• Bupivacaine
General anesthesia combined with thoracic epidural 0.25% bupivacaine
• Ropivacaine
General anesthesia combined with thoracic epidural 0.3% ropivacaine
• Normal Saline
General anesthesia combined with thoracic epidural 0.9% normal saline

Locations
Country Name City State
n/a

Sponsors (1)
Lead Sponsor Collaborator
First Hospital of China Medical University

Outcome
Type Measure Description Time frame Safety issue
Primary Propofol Effect-site Concentration The effect-site concentration of propofol when loss of consciousness during propofol target-controlled infusing(TCI) induction of anesthesia. Before starting anesthesia to finishing endotracheal intubation No
Secondary Mean Arterial Pressure The mean arterial pressure of each patient was recorded at five different time points Before starting anesthesia to finishing endotracheal intubation No
Secondary Heart Rate The heart rate of each patient was recorded at five different time points Before starting anesthesia to finishing endotracheal intubation No
Secondary Bispectral Index Score The bispectral index(BIS) score of each patient was recorded at two different time points. BIS values varies from 0 to 100(0, no cerebral activity; 40 to 60, general anesthesia; 60 to 85, sedated; 85 to 100, awake). Before starting anesthesia to finishing endotracheal intubation No
See also
  Status Clinical Trial Phase
Completed NCT04577430 - Effects of Dexmedetomidine on Cardiac Electrophysiology in Patients Under General Anesthesia During Perioperative Period N/A
Completed NCT03708692 - Menstrual Cycle Phases on Recovery and Cognitive Function
Recruiting NCT03422315 - Population Pharmacokinetics and Clinical Individual Dosage Regimen of Propofoll Injection N/A
Completed NCT02771067 - The Utility of Pulse Pressure Variation to Predict the Fluid Responsiveness During Pneumoperitoneum and Reverse-Trendelenburg Position N/A
Completed NCT05063461 - Evaluation of the Analgesia Nociception Index With Varying Remifentanil Concentrations Under Sevoflurane N/A
Completed NCT03294226 - Comparison of AuraGain With I-gel for Pediatric Patients N/A
Not yet recruiting NCT03643029 - The Accuracy of the Performance and Placement Test for Predicting Supraglottic Airway Device (SAD) Position in the Hypopharynx as Confirmed With Video Laryngoscopy N/A
Completed NCT01945411 - Assessment of Facial Measurements, the Length of Mouth Corner-mandible Angle and Incisors-mandible Angle, for Determining the Proper Sizes of Oropharyngeal Airway N/A
Completed NCT01705743 - Minimum Alveolar Concentration of Sevoflurane With Nitrous Oxide Inducing Isoelectric EEG Phase 4
Not yet recruiting NCT01678066 - A Prospective Study to Bilaterally Compare a Non-Invasive Cardiac Output Monitor N/A
Completed NCT00972491 - The Optimal Time to Put Laryngeal Mask Airway in the Mouth Under General Anesthesia N/A
Completed NCT00741507 - Unhealthy Alcohol Drinking and Anesthetic Requirement in Women N/A
Completed NCT01096212 - Efficacy and Safety of Sevofran in Patients Scheduled for Elective Surgery Under General Anesthesia Phase 4
Completed NCT00599066 - Intraoperative M-Entropy Measurements N/A
Completed NCT00532402 - Continuous and Discontinuous Determination of Propofol Concentration in Breathing Gas N/A
Completed NCT00468494 - Can Blood Glucose Levels During the Perioperative Period Identify a Population at Risk for Hyperglycemia? N/A
Recruiting NCT00492453 - Spinal Versus General Anesthesia for Laparoscopic Cholecystectomy N/A
Recruiting NCT03745079 - Correlation Between Core Temperature and Skin Temperature Measured by 3M SpotOn
Completed NCT04094376 - Comparison of Morning Operation and Evening Operation on Postoperative Sleep Quality and Pain Under General Anesthesia N/A
Enrolling by invitation NCT03672734 - Volume and pH of Gastric Contents in Patients Undergoing Gynecologic Laparoscopic Surgery During Emergence From General Anesthesia