Bolton CM, Myles PS, Carlin JB, Nolan T Randomized, double-blind study comparing the efficacy of moderate-dose metoclopramide and ondansetron for the prophylactic control of postoperative vomiting in children after tonsillectomy. Br J Anaesth. 2007 Nov;99(5):699-703. Epub 2007 Aug 21.
Golparvar M, Saghaei M, Saadati MA, Farsaei S Effect of ondansetron on prevention of post-induction hypotension in elderly patients undergoing general anesthesia: A randomized, double-blind placebo-controlled clinical trial. Saudi J Anaesth. 2015 Oct-Dec;9(4):365-9. doi: 10.4103/1658-354X.159455.
Groothuis JT, van Vliet L, Kooijman M, Hopman MT Venous cuff pressures from 30 mmHg to diastolic pressure are recommended to measure arterial inflow by plethysmography. J Appl Physiol (1985). 2003 Jul;95(1):342-7. Epub 2003 Apr 4.
Kyriakides K, Hussain SK, Hobbs GJ Management of opioid-induced pruritus: a role for 5-HT3 antagonists? Br J Anaesth. 1999 Mar;82(3):439-41.
Lee SK Pain on injection with propofol. Korean J Anesthesiol. 2010 Nov;59(5):297-8. doi: 10.4097/kjae.2010.59.5.297. Epub 2010 Nov 25.
Macario A, Weinger M, Truong P, Lee M Which clinical anesthesia outcomes are both common and important to avoid? The perspective of a panel of expert anesthesiologists. Anesth Analg. 1999 May;88(5):1085-91.
Mahler SA, Massey G, Meskill L, Wang H, Arnold TC Can we make the basilic vein larger? maneuvers to facilitate ultrasound guided peripheral intravenous access: a prospective cross-sectional study. Int J Emerg Med. 2011 Aug 25;4:53. doi: 10.1186/1865-1380-4-53.
Mangar D, Holak EJ Tourniquet at 50 mm Hg followed by intravenous lidocaine diminishes hand pain associated with propofol injection. Anesth Analg. 1992 Feb;74(2):250-2.
Marik PE Propofol: therapeutic indications and side-effects. Curr Pharm Des. 2004;10(29):3639-49. Review.
Massad IM, Abu-Ali HM, Abu-Halaweh SA, Badran IZ Venous occlusion with lidocaine for preventing propofol induced pain. A prospective double-blind randomized study. Saudi Med J. 2006 Jul;27(7):997-1000.
McCrirrick A, Hunter S Pain on injection of propofol: the effect of injectate temperature. Anaesthesia. 1990 Jun;45(6):443-4.
Paventi S, Santevecchi A, Ranieri R Efficacy of a single-dose ondansetron for preventing post-operative nausea and vomiting after laparoscopic cholecystectomy with sevoflurane and remifentanil infusion anaesthesia. Eur Rev Med Pharmacol Sci. 2001 Mar-Apr;5(2):59-63.
Picard P, Tramèr MR Prevention of pain on injection with propofol: a quantitative systematic review. Anesth Analg. 2000 Apr;90(4):963-9.
Powell RM, Buggy DJ Ondansetron given before induction of anesthesia reduces shivering after general anesthesia. Anesth Analg. 2000 Jun;90(6):1423-7.
Reddy MS, Chen FG, Ng HP Effect of ondansetron pretreatment on pain after rocuronium and propofol injection: a randomised, double-blind controlled comparison with lidocaine. Anaesthesia. 2001 Sep;56(9):902-5.
Rosenberg PH, Heavner JE Multiple and complementary mechanisms produce analgesia during intravenous regional anesthesia. Anesthesiology. 1985 Jun;62(6):840-2.
Tan CH, Onsiong MK Pain on injection of propofol. Anaesthesia. 1998 May;53(5):468-76. Review.
Tramèr MR, Reynolds DJ, Moore RA, McQuay HJ Efficacy, dose-response, and safety of ondansetron in prevention of postoperative nausea and vomiting: a quantitative systematic review of randomized placebo-controlled trials. Anesthesiology. 1997 Dec;87(6):1277-89.
van Zundert A, Helmstädter A, Goerig M, Mortier E Centennial of intravenous regional anesthesia. Bier's Block (1908-2008). Reg Anesth Pain Med. 2008 Sep-Oct;33(5):483-9. doi: 10.1016/j.rapm.2008.04.011.
Williamson A, Hoggart B Pain: a review of three commonly used pain rating scales. J Clin Nurs. 2005 Aug;14(7):798-804. Review.
Ye JH, Ponnudurai R, Schaefer R Ondansetron: a selective 5-HT(3) receptor antagonist and its applications in CNS-related disorders. CNS Drug Rev. 2001 Summer;7(2):199-213. Review.
Interventional studies are often prospective and are specifically tailored to evaluate direct impacts of treatment or preventive measures on disease.
Observational studies are often retrospective and are used to assess potential causation in exposure-outcome relationships and therefore influence preventive methods.
Expanded access is a means by which manufacturers make investigational new drugs available, under certain circumstances, to treat a patient(s) with a serious disease or condition who cannot participate in a controlled clinical trial.
Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.
Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.