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Clinical Trial Details — Status: Completed

Administrative data

NCT number NCT01723410
Other study ID # GGSC-GRAT
Secondary ID
Status Completed
Phase N/A
First received November 1, 2012
Last updated December 10, 2015
Start date January 2013
Est. completion date January 2015

Study information

Verified date December 2015
Source University of California, Los Angeles
Contact n/a
Is FDA regulated No
Health authority United States: Institutional Review Board
Study type Interventional

Clinical Trial Summary

UCLA researchers looking for healthy individuals (aged 35-50) who have a home computer with internet access, are not pregnant, planning to become pregnant, or currently breastfeeding (if female), to participate in a study investigating whether real-world experiences alter the brain and body. This study takes place over an eight week period and involves providing the names of 8 close friends or family members, completing a neuroimaging session, providing blood and saliva (for genetic analysis), and a 6-week period in which participants login twice a week to complete online questionnaires. Compensation is up to $210 for those who complete all aspects of the study. Please email realworld.ucla@gmail.com for more information.


Recruitment information / eligibility

Status Completed
Enrollment 70
Est. completion date January 2015
Est. primary completion date January 2015
Accepts healthy volunteers Accepts Healthy Volunteers
Gender Both
Age group 35 Years to 50 Years
Eligibility Inclusion Criteria:

- Healthy adults between the ages of 35-50

Exclusion Criteria:

Following a structured telephone interview, prospective participants with the following conditions will not be able to participate:

1. claustrophobia, left-handedness, or presence of metal in their body (for the neuroimaging procedures),

2. possible presence of a depressive disorder, which may interfere with the gratitude intervention (assessed by the Patient Health Questionnaire; Spitzer et al., 1999),

3. regular use of medications that may impact inflammatory processes (anti-inflammatory drugs, steroids, opioids),

4. current smokers or excessive caffeine users (> 600 mg/day) because of known effects on inflammation, and

5. pregnancy (which would affect oxytocin gene expression).

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Basic Science


Related Conditions & MeSH terms


Intervention

Behavioral:
Writing about people
Subjects will be asked to write about other people in their lives once a week for 6-weeks.
Other:
Writing about places, objects


Locations

Country Name City State
United States UCLA CTRC & Brain Mapping Center Los Angeles California

Sponsors (1)

Lead Sponsor Collaborator
University of California, Los Angeles

Country where clinical trial is conducted

United States, 

Outcome

Type Measure Description Time frame Safety issue
Primary inflammatory gene expression Changes in inflammatory gene expression from pre- to post-intervention. baseline, six weeks post manipulation No
Secondary neural activity Changes in neural activity from pre- to post-intervention. baseline, six weeks post-intervention No
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