Gender Clinical Trial - The Impact of Gender on Graft Outcomes Following

Status Completed

Clinical Trial Summary

The impact of donor and recipient gender combination on kidney transplant outcomes has been reported in several studies. The results vary greatly due to different factors, such as minor histocompatibility antigens, nephron overload, sex hormones, etc. Despite advancements in clinical practice, no large-scale studies exploring this question in living donor kidney transplantation have been conducted in the subsequent two decades. Our study aims to address this research gap and provide updated information on outcomes in relation to the gender combination following living donor kidney transplantation.

Clinical Trial Description

The impact of donor and recipient gender combination on kidney transplant outcomes has been reported in several studies, but with inconclusive results. From an immunologic perspective, the transplantation of male donor kidneys into female recipients was associated with an increased risk of graft failure and mortality due to H-Y minor histocompatibility antigens. Another theory, based on nephron overload and hyperfiltration, suggests that male recipients of female donor kidneys tend to experience worse outcomes due to the smaller size of female kidneys. Additionally, the influence of sex hormones has been explored. Aufhauser et al. found that estrogen acts as a protective factor against ischemia-reperfusion injury (IRI), resulting in a significantly lower incidence of delayed graft function (DGF) in female recipients compared to male recipients. These findings seem conflicting, and most of studies have primarily focused on deceased donor kidney transplantation. In addition, Kayler et al. analyzed a transplant database encompassing 30,258 living donor kidney transplantations between 1990 and 1999. Their study revealed a significant advantage in graft survival for male recipients of male donor kidneys compared to the other combinations. Another study involving 5,716 HLA-identical sibling kidney transplantations between 1985 and 2000 demonstrated that female recipients tend to have better graft survival rates regardless of the donor's gender. Despite advancements in clinical practice, no such large-scale studies exploring this question have been conducted in the subsequent two decades. Our study aims to address this research gap and provide updated information on outcomes in relation to the gender combination following living donor kidney transplantation. ;

Study Design

Related Conditions & MeSH terms

Gender
Kidney Transplant Failure and Rejection

Clinical Trial Details

NCT number	NCT06016283
Study type	Observational
Source	Erasmus Medical Center
Contact
Status	Completed
Phase
Start date	April 1, 2022
Completion date	June 30, 2023

View Details

See also
Status	Clinical Trial	Phase
Not yet recruiting	`NCT06441942` - Prospective Multicenter Registry of Gender, Diversity and Inclusion (GEDI) of Women With Acute Coronary Syndrome
Recruiting	`NCT05593692` - Gender Differences and Age Related Differences in Emergency Department Admission
Active, not recruiting	`NCT06345573` - Heart-brain-axis and Psychosocial Stress
Completed	`NCT01571128` - Gender-Specific Combination HIV Prevention for Youth in High Burden Settings (MP3-Youth)	N/A
Completed	`NCT06138119` - The Impact of Gender Stereotypes on Fiberoptic Intubation Performance	N/A
Active, not recruiting	`NCT03884608` - Analysis of Both Sex and Device Specific Factors on Outcomes in Patients With Non-Ischemic Cardiomyopathy
Recruiting	`NCT05789667` - Gender-based Impact on Safety and Efficacy of Lenvatinib in Patients With Differentiated Thyroid Cancer
Not yet recruiting	`NCT06018623` - Dosage of Propofol Based on Lean Body Weight
Completed	`NCT03534375` - Gender Differences of Neuroanatomical and Neurophysiological Correlates of Risk-proneness in Early Adolescents
Completed	`NCT02651233` - Factors That Influence Adipose Derived Regenerative Cells' Yield and Viability	N/A
Completed	`NCT04077151` - Transgender Youth and PrEP: PK, Safety, Uptake & Adherence - Demonstration Project	N/A
Not yet recruiting	`NCT05686187` - Establishing and Evaluating the Effectiveness of an Augmented Reality Technology in Gender Empowerment System	N/A
Active, not recruiting	`NCT03890237` - GAGE Act With Her-Ethiopia Evaluation	N/A
Completed	`NCT06357325` - 2023 Problems Faced by Women Earthquake Survivors in Kahramanmaraş
Completed	`NCT02532725` - Work-Related Effects of Heat, Activity, and Fat in Middle Aged Men	N/A
Completed	`NCT03652623` - Transgender Youth and PrEP: PK, Safety, Uptake & Adherence - PK Study	Phase 1/Phase 2
Completed	`NCT04452539` - Gender Influence on Morbi-mortality in Pediatric Cardiac Surgery.
Completed	`NCT06391060` - Gender Differences in Robotic Surgery for Rectal Cancer: a Retrospective Study
Recruiting	`NCT04440761` - Barts-MINOCA Registry
Completed	`NCT03281213` - Acute Postthoracotomy Pain - Impact of Gender	N/A

Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.

The Impact of Gender on Graft Outcomes Following Living Donor Kidney Transplantation

Clinical Trial Summary

Clinical Trial Description

Study Design

Related Conditions & MeSH terms