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A Study of Ripretinib vs Sunitinib in Advanced GIST Patients After Treatment With Imatinib — INTRIGUE  

Gastrointestinal Stromal Tumors Clinical Trial

Official title:
A Phase 3, Interventional, Randomized, Multicenter, Open-Label Study of Ripretinib vs Sunitinib in Patients With Advanced Gastrointestinal Stromal Tumor (GIST) After Treatment With Imatinib

Clinical Trial Summary

This is a 2-arm, randomized, open-label, international, multicenter study comparing the efficacy of ripretinib to sunitinib in GIST patients who progressed on or were intolerant to first-line anticancer treatment with imatinib. Approximately 426 patients will be randomized in a 1:1 ratio to ripretinib 150 mg once daily (continuous dosing for 6 week cycles) or sunitinib 50 mg once daily (6 week cycles, 4 weeks on, 2 weeks off).

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03673501
Study type Interventional
Source Deciphera Pharmaceuticals LLC
Contact
Status Active, not recruiting
Phase Phase 3
Start date February 8, 2019
Completion date December 2024
View Details
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