Masitinib in First Line Treatment of Gastro-Intestinal Stromal Tumor

Status Terminated

Clinical Trial Summary

Masitinib in First Line Treatment of Gastro-Intestinal Stromal Tumor (GIST)

Clinical Trial Description

Masitinib is a selective tyrosine kinase inhibitor with potent activity against wild-type c-Kit, the juxta membrane domain of c-Kit, and PDGFR. In addition to its direct inhibitory action against these kinase targets, masitinib is also thought to promote survival via modulation of immunostimulation-mediated anticancer effects and modulation of the tumor microenvironment. The objective of this prospective, multicenter, randomized, open-label, active-controlled study is to compare the efficacy and safety of masitinib with respect to imatinib in the first line treatment of gastro-intestinal stromal tumor (GIST). Treatment will be given until disease progression, limiting toxicity or patient consent withdrawal. ;

Study Design

Related Conditions & MeSH terms

Gastrointestinal Stromal Tumors

Clinical Trial Details

NCT number	NCT00812240
Study type	Interventional
Source	AB Science
Contact
Status	Terminated
Phase	Phase 3
Start date	January 2009
Completion date	July 2018

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See also
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