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Clinical Trial Summary

Ultrasonic sonoporation can increase the release of chemotherapeutics, thus increasing the therapeutic effects. The main purpose is to identify the safety of combining ultrasonic microbubbles and chemotherapeutics to treat malignant neoplasms of hepatic metastases from alimentary system and pancreatic carcinoma.


Clinical Trial Description

Ultrasonic sonoporation can increase the release of chemotherapeutics, thus increasing the therapeutic effects.

1. Main purpose

1. To identify the safety of combining ultrasonic microbubbles and chemotherapeutics to treat malignant neoplasms of hepatic metastases from alimentary system and pancreatic carcinoma.

2. To explore the largest mechanical index and ultrasonic treatment time which patients can endure.

2. Secondary purpose

1. To observe tumor clinical benefit rate (CR+PR+SD).

2. To evaluate the preliminary effect,such as time to failure(TTF), time to death(TTD) ;


Study Design

Endpoint Classification: Safety Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment


Related Conditions & MeSH terms


NCT number NCT02233205
Study type Interventional
Source Beijing Cancer Hospital
Contact Yang Wei, Doctor
Phone 0086-10-88196195
Email 13681408183@163.com
Status Recruiting
Phase Phase 1/Phase 2
Start date October 2014
Completion date June 2016

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