Gastrointestinal Microbiome Clinical Trial
Official title:
An Observational Study of Intestinal Flora in Infants
The purpose of this study is to investigate the influence factors of gastrointestinal microbiome in infants.
The gastrointestinal microbiome is believed to be critically important for infant growth and
development. As we all know, the gut microbiota can influence gut maturation, metabolic,
immune and brain development in early life. Host genotype, gestational age, antibiotic use,
mode of delivery, diet and the context in which the infant is born (rural vs urban, presence
of siblings, pets and other factors) can influence the development of infant gut microbiota.
In the early life stage, intestinal flora disorders may alter the host immune function and
increase the susceptibility to immune or metabolic diseases.
This research intends to establish a birth cohort of healthy newborns. The influence factors
of gastrointestinal microbiome will be investigated by means of questionnaire survey,
specimen collection and high throughput sequencing analysis. What's more, the correlation of
gut microbiome, infant growth as well as related diseases will be explored either. The
results will provide constructive suggestions for the establishment of infant normal
intestinal flora and play an indispensable role in exploring the occurrence, development and
prevention of related diseases.
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