Clinical Translation of a Novel FAPI Dimer [68Ga]Ga-LNC1013

Status Completed

Clinical Trial Summary

Fibroblast activation protein (FAP) emerges as a highly promising target for cancer diagnostic imaging and targeted radionuclide therapy. To exploit the therapeutic potential of current FAP inhibitors (FAPIs), this study presented the design and synthesis of a series of FAPI dimers to increase tumor uptake and retention. Preclinical evaluation and a pilot clinical PET imaging study were conducted to screen the lead compound with the potential for radionuclide therapy.

Clinical Trial Description

Three new FAPI dimers were synthesized by linking two quinoline-based FAPIs with different spacers. The in vitro binding affinity and preclinical small animal PET imaging of the compounds were compared with their monomeric counterparts, FAPI-04 and FAPI-46. The lead compound, 68Ga-LNC1013, was then evaluated in a pilot clinical PET imaging study involving seven patients with gastrointestinal cancer. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT06159049
Study type	Observational [Patient Registry]
Source	Xiangya Hospital of Central South University
Contact
Status	Completed
Phase
Start date	July 21, 2022
Completion date	November 25, 2022

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