Management of Oxaliplatin-related Gastroesophageal Variceal Bleeding

Status Recruiting

Clinical Trial Summary

In this randomized controlled study, we aim to compare the efficacy and safety of these two interventions in patients with oxaliplatin-induced gastroesophageal variceal bleeding.

Clinical Trial Description

Oxaliplatin is used as the first-line chemotherapy for colorectal cancer. However, oxaliplatin-induced hepatotoxicity could lead to sinusoidal injury and portal hypertension in the long term. Variceal bleeding, as the most common complication of portal hypertension, threaten these patents' life. Endoscopic treatment and Transjugular Intrahepatic Portosystemic Shunt (TIPS) are both recommended management of gastroesophageal variceal bleeding. In this randomized controlled study, we aim to compare the efficacy and safety of these two interventions in patients with oxaliplatin-induced gastroesophageal variceal bleeding. ;

Study Design

Related Conditions & MeSH terms

Gastroesophageal Varices Hemorrhage
Gastrointestinal Cancer
Gastrointestinal Neoplasms
Hemorrhage
Received Oxaliplatin-based Chemotherapy

Clinical Trial Details

NCT number	NCT05141617
Study type	Interventional
Source	Shanghai Zhongshan Hospital
Contact	Xiaoquan HUANG, M.D.
Phone	008618801733835
Email	huang.xiaoquan@zs-hospital.sh.cn
Status	Recruiting
Phase	N/A
Start date	November 3, 2021
Completion date	December 31, 2023

View Details

See also
Status	Clinical Trial	Phase
Enrolling by invitation	`NCT00068003` - Harvesting Cells for Experimental Cancer Treatments
Not yet recruiting	`NCT05044312` - Sleep Disturbances in Surgical Patients With GI Cancers: A Quantitative and Qualitative Analysis	N/A
Active, not recruiting	`NCT05053191` - Advancing Nursing Practices in Hospital Oncology Care	N/A
Completed	`NCT03611309` - Perioperative Palliative Care Surrounding Cancer Surgery for Patients & Their Family Members	N/A
Recruiting	`NCT03602677` - Indocyanine Green Fluorescence Imaging in Prevention of Colorectal Anastomotic Leakage	N/A
Recruiting	`NCT03190941` - Administering Peripheral Blood Lymphocytes Transduced With a Murine T-Cell Receptor Recognizing the G12V Variant of Mutated RAS in HLA-A*11:01 Patients	Phase 1/Phase 2
Not yet recruiting	`NCT06398314` - Palliative Radiotherapy in Symptomatic Pelvic Soft Tissue Tumors	N/A
Withdrawn	`NCT04030624` - Remote Electronic Patient Monitoring in Gastrointestinal Cancer	N/A
Completed	`NCT02140593` - The Laparotomy Study	Phase 4
Completed	`NCT02222259` - A Feasibility Trial of Geriatric Assessment and Management for Older Cancer Patients	N/A
Active, not recruiting	`NCT00716209` - Infrastructure for Developing Gastrointestinal Cancer Prognostic and Predictive Markers	N/A
Recruiting	`NCT01484444` - Biomarker Analysis of Gastrointestinal Cancer	N/A
Completed	`NCT02130427` - A Volume, Motion, and Anatomically Adaptive Approach to Photon and Proton Beam Radiotherapy	N/A
Active, not recruiting	`NCT00710632` - Screening to Predict Weight Loss in Patients With Cancer	N/A
Completed	`NCT00094965` - Oxaliplatin With FOLFOX4 in Patients With Normal and Abnormal Renal Function	Phase 2
Terminated	`NCT04077372` - Assessment of a Serious Illness Conversation Guide (SICG) in Advanced Gastro-Intestinal Cancers	N/A
Recruiting	`NCT04899908` - Stereotactic Brain-directed Radiation With or Without Aguix Gadolinium-Based Nanoparticles in Brain Metastases	Phase 2
Recruiting	`NCT05429866` - Immunological Variables Associated to ICI Toxicity in Cancer Patients	Phase 2
Recruiting	`NCT05226221` - Gastrointestinal Emergency Surgery: Evaluation of Morbidity and Mortality
Recruiting	`NCT03286348` - Analysis of Nutrition During Chemoradiotherapy in Patients With Gastrointestinal Cancer	N/A