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NCT04883970 Clinical Trial

CLDN18.2 Targeting PET Imaging in Patients With Gastrointestinal Tumors

Gastrointestinal Cancer Clinical Trial

Official title:
CLDN18.2 Targeting 124I-18B10(10L) PET Imaging in Patients With Gastrointestinal Tumors

Clinical Trial Details — Status: Active, not recruiting

Administrative data
NCT number NCT04883970
Other study ID # 2021KT57
Secondary ID
Status Active, not recruiting
Phase N/A
First received
Last updated
Start date May 13, 2021
Est. completion date May 2024

Study information
Verified date January 2024
Source Peking University Cancer Hospital & Institute
Contact n/a
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

The objective of the study is to constrcut a noninvasive approach 124I-18B10(10L) PET/CT to detect the CLDN18.2 expression of tumor lesions in patients with gastrointestinal tumors and to identify patients benefiting from CLDN18.2 targeting treatment.

Recruitment information / eligibility
Status Active, not recruiting
Enrollment 15
Est. completion date May 2024
Est. primary completion date May 2024
Accepts healthy volunteers No
Gender All
Age group 18 Years and older
Eligibility Inclusion Criteria: - 1. Aged >18 years old; ECOG 0 or 1; - 2. Patients with Gastrointestinal tumors; - 3. Has at least one measurable target lesion according to Response Evaluation Criteria in Solid Tumors (RECIST V1.1); - 4. life expectancy >=12 weeks. Exclusion Criteria: - 1. Significant hepatic or renal dysfunction; - 2. Is pregnant or ready to pregnant; - 3. Cannot keep their states for half an hour; - 4. Refusal to join the clinical study; - 5. Suffering from claustrophobia or other mental diseases; - 6. Any other situation that researchers think it is not suitable to participate in the experiment.

Study Design

Related Conditions & MeSH terms

Intervention

Other:
• 124I-18B10(10L) PET/CT
Study participants will undergo 124I-18B10(10L) PET/CT scans

Locations
Country Name City State
China HUA ZHU Beijing

Sponsors (1)
Lead Sponsor Collaborator
Peking University Cancer Hospital & Institute

Country where clinical trial is conducted

China, 

Outcome
Type Measure Description Time frame Safety issue
Primary Standardized uptake value(SUV) 2 years
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