Gastrointestinal Cancer Clinical Trial
Official title:
Phase II Study of Efficacy of Radiotherapy in Combination With Zoledronic Acid on Pain Relief in Bone Metastasis Patients With Gastrointestinal Tumors
Bone metastasis causes bone destruction and skeletal related events (SRE) including
compression fracture, hypercalcemia, and spinal cord compression. Therefore, palliative
treatments for pain control and local control have become important and multidisciplinary
multimodality approach is needed for treatment of bone metastasis.
The efficacy of radiotherapy (RT) for bone metastasis is well known. And the results that
bisphosphonate decreases SRE in patients with solid tumor and multiple myeloma reported. In
previous retrospective reports, the combination of local RT and systemic bisphosphonate was
more effective than RT alone.
Therefore, the investigators designed a phase II study to evaluate the efficacy of RT in
combination with zoledronic acid on pain relief and the safety of RT in bone metastasis
patients with gastrointestinal tumors.
n/a
Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
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