The Role of HIF-2a in the Pathogenesis of Reflux Esophagitis

Status Completed

Clinical Trial Summary

The purpose of this study is to determine the role of hypoxia inducible factor (HIF)-2a on the production of inflammatory cytokines that lead to reflux esophagitis.

Clinical Trial Description

Reflux esophagitis is thought to be caused by gastric acid that refluxes into the esophagus, causing injury. Newer data suggest that reflux of gastric juice into the esophagus stimulates HIF-2a, which increases production of inflammatory cytokines. These cytokines are thought to lead to reflux esophagitis. The investigators plan to study the relationship of HIF-2a to inflammatory cytokines in patients with known gastroesophageal reflux disease and reflux esophagitis. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT01733810
Study type	Interventional
Source	Dallas VA Medical Center
Contact
Status	Completed
Phase	N/A
Start date	February 1, 2013
Completion date	July 31, 2019

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