Symptom Assessment for GERD Patients Receiving H. Pylori Eradication

Status Recruiting

Clinical Trial Summary

Clinical Trial Description

Background: Rebound acid hypersecretion and acid-related symptoms after discontinuation of proton-pump inhibitor has been reported in previous studies. In patients with concurrent gastro-esophageal reflux disease and Helicobacter pylori infection, whether eradication of H. pylori will aggravate acid-related symptoms after discontinuation of proton-pump inhibitor remains elusive Objective: This study aims to investigate the incidence and severity of acid-related symptoms after discontinuation of proton-pump inhibitor in reflux patients receiving H. pylori eradication Patients and methods: Consecutive reflux patients documented by validated questionnaires (GerdQ) and upper endoscopy will be enrolled from the outpatient clinic. After determination of H. pylori status by urea breath test, those with positive H. pylori infection will be randomized into two groups. Group A (n=100) will be given initial H. pylori eradication with triple therapy for one week, followed by proton-pump inhibitor (PPI) with rabeprazole 20 mg qd for 7 weeks. Group B (n=100) will be given rabeprazole 20 mg qd for 8 weeks and discontinued for 2 weeks. Then, H. pylori eradication with triple therapy will be given for one week, followed by rabeprazole 20 mg qd for 7 weeks. For patients with negative H. pylori infection (n=100), proton-pump inhibitor with rabeprazole 20 mg qd will be given for 8 weeks and discontinued. The incidence and severity of acid-related symptoms will be evaluated with GerdQ at 2 weeks after discontinuation of PPI. The impact of H. pylori infection and H. pylori eradication on the incidence and severity of acid-related symptoms after discontinuation of proton-pump inhibitor will be analyzed. ;

Study Design

Observational Model: Case Control, Time Perspective: Prospective

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT01249482
Study type	Observational
Source	National Taiwan University Hospital
Contact	Yi-Chia Lee, MD,PhD
Phone	886-2-23123456
Email	yichialee@ntu.edu.tw
Status	Recruiting
Phase	N/A
Start date	September 2010
Completion date	August 2012

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT02135107` - A Double-blind Comparative Study of the Efficacy and Safety of E3810 10mg Once and Twice Daily in Maintenance Therapy for PPI Resistant Gastroesophageal Reflux Disease Patients	Phase 3
Completed	`NCT01432392` - Symptom Control and Impact on Daily Life in Patients With Gastroesophageal Reflux Disease	N/A
Completed	`NCT01200550` - The Study to Describe Symptom Control and Impact on Daily Life in Gastroesophageal Reflux Disease (GERD) Patients	N/A
Completed	`NCT01578642` - Feasibility Study for Evaluating the Effect of Electrical Stimulation on Lower Esophageal Sphincter Pressure and Esophageal Acid Exposure in Patients With Gastroesophageal Reflux Disease	Phase 2
Completed	`NCT00978016` - A Study to Evaluate the Efficacy and Safety of Arbaclofen Placarbil (XP19986) as Adjunctive Therapy in Subjects With Gastroesophageal Reflux Disease (GERD)	Phase 2
Completed	`NCT00998244` - Study to Evaluate the Effect of a Very Low Carbohydrate Diet on Gastroesophageal Reflux Disease	N/A
Unknown status	`NCT01128608` - The Effect of High PCO2 Solution on Esophageal Acid Sensation	N/A
Completed	`NCT00768196` - Prevalence of EED and Quality of Life Evaluated by Gastroesophageal Reflux Disease (GERD)-Q in Korean GERD Patients	N/A
Completed	`NCT00768443` - Symptoms and Management Strategies in Gastroesophageal Reflux Disease (GERD)	N/A
Recruiting	`NCT00498082` - Determinants of Efficacy of EsophyX Treatment in Gastro-Esophageal Reflux Disease	N/A
Completed	`NCT00886197` - Diagnostic Efficacy of Narrow Band Imaging in Patients With Gastroesophageal Reflux Disease	N/A
Completed	`NCT00378898` - Feasibility of Placing Bravo PH Capsule in Proximal Esophagus	N/A
Completed	`NCT00507377` - Foreshortened Esophagus and Its Surgical Therapy
Completed	`NCT00217347` - Evaluation of Efficiency of Esophageal Capsule Endoscopy in the Screening of Patients With Gastroesophageal Reflux Disease or Dyspepsia as Compared to Upper Endoscopy	N/A
Completed	`NCT00165022` - Development of a Novel Disease-Specific Quality of Life Questionnaire for Gastroesophageal Reflux Disease (GERD) Patients in Chinese Population	N/A
Completed	`NCT00214552` - Evaluate the Effects on Asthma Control of Rabeprazole Given Twice Daily in Subjects With Asthma.	Phase 3
Completed	`NCT00625495` - Study Comparing the Effects of Esomeprazole Adminstered Orally and Intravenously on Basal and Pentrigastrin-stimulated Acid Output in Subjects With Symptoms of Gastroesophageal Reflux Disease (GERD)	Phase 4
Completed	`NCT00618150` - Patient Education in Gastroesophageal Reflux Disease	N/A
Completed	`NCT03299985` - Diaphragmatic Myofascial Release in Gastroesophageal Reflux Disease	N/A
Completed	`NCT03284177` - A Trial of C13-CAC Breath Test in PPI Resistant GERD Patients	Phase 2