Gastroesophageal Reflux Disease Clinical Trial
GERD is due to gastric content reflux to esophagus cause symptom and complication including
intra-esophagus such as reflux esophagitis, and extra-esophagus such as cough etc. Because
the changes of dietary habit, and improvement of examination skill and data analysis, the
prevalence of GERD increased 2.5 multiple from 1995 to 2002, and suggesting the prevalence
is 25% in Taiwan community.
Although proton pump inhibitor (PPI) can inhibit gastric acid secretion, relief symptom and
enhancing repair of esophageal damage, therefore, PPI is a main drug for the treatment of
GRED, but because of PPI has disadvantage of poor compliance, and slow gastric empty time
and hypersensitivity, and about 40-50% of GERD patients is inefficacy. In addition, PPI
produces bone fracture, community pneumonia and diarrhea in patient with long-term use.
Wu-Chu-Yu tang consists of Evodia fargesii Dode (Evodia Fruit), Panax ginseng C. (Ginseng),
Ziziphus jujube Mill (Chinses Date), Zingiber officinale Rosee (Fresh Ginger). According to
"I-Fang-Chi-Chieh" and "Shanghonzobinglun" recordings that Wu-Chu-Yu tang can treat
vomiting, and also can relax gastric tonicity and can enhance peristalsis of stomach.
Therefore, the purpose of the present study was to investigate the efficacy of Wu-Chu-Yu
tang on GRED, and this effect of Wu-Chu-Yu tang compared to PPI Omeprazole.
n/a
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
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A Double-blind Comparative Study of the Efficacy and Safety of E3810 10mg Once and Twice Daily in Maintenance Therapy for PPI Resistant Gastroesophageal Reflux Disease Patients
|
Phase 3 | |
| Completed |
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Symptom Control and Impact on Daily Life in Patients With Gastroesophageal Reflux Disease
|
N/A | |
| Recruiting |
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Symptom Assessment for GERD Patients Receiving H. Pylori Eradication
|
N/A | |
| Completed |
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The Study to Describe Symptom Control and Impact on Daily Life in Gastroesophageal Reflux Disease (GERD) Patients
|
N/A | |
| Completed |
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Feasibility Study for Evaluating the Effect of Electrical Stimulation on Lower Esophageal Sphincter Pressure and Esophageal Acid Exposure in Patients With Gastroesophageal Reflux Disease
|
Phase 2 | |
| Completed |
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|
N/A | |
| Completed |
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A Study to Evaluate the Efficacy and Safety of Arbaclofen Placarbil (XP19986) as Adjunctive Therapy in Subjects With Gastroesophageal Reflux Disease (GERD)
|
Phase 2 | |
| Unknown status |
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|
N/A | |
| Completed |
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Symptoms and Management Strategies in Gastroesophageal Reflux Disease (GERD)
|
N/A | |
| Completed |
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Prevalence of EED and Quality of Life Evaluated by Gastroesophageal Reflux Disease (GERD)-Q in Korean GERD Patients
|
N/A | |
| Recruiting |
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|
N/A | |
| Completed |
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Diagnostic Efficacy of Narrow Band Imaging in Patients With Gastroesophageal Reflux Disease
|
N/A | |
| Completed |
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Feasibility of Placing Bravo PH Capsule in Proximal Esophagus
|
N/A | |
| Completed |
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Foreshortened Esophagus and Its Surgical Therapy
|
||
| Completed |
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|
N/A | |
| Completed |
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Development of a Novel Disease-Specific Quality of Life Questionnaire for Gastroesophageal Reflux Disease (GERD) Patients in Chinese Population
|
N/A | |
| Completed |
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Evaluate the Effects on Asthma Control of Rabeprazole Given Twice Daily in Subjects With Asthma.
|
Phase 3 | |
| Completed |
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Study Comparing the Effects of Esomeprazole Adminstered Orally and Intravenously on Basal and Pentrigastrin-stimulated Acid Output in Subjects With Symptoms of Gastroesophageal Reflux Disease (GERD)
|
Phase 4 | |
| Completed |
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Patient Education in Gastroesophageal Reflux Disease
|
N/A | |
| Completed |
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Diaphragmatic Myofascial Release in Gastroesophageal Reflux Disease
|
N/A |