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Gastroesophageal Junction clinical trials

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NCT ID: NCT03132922 Active, not recruiting - Ovarian Cancer Clinical Trials

MAGE-A4ᶜ¹º³²T for Multi-Tumor

Start date: May 15, 2017
Phase: Phase 1
Study type: Interventional

This study will investigate the safety and tolerability of MAGE-A4ᶜ¹º³²T cell therapy in subjects who have the appropriate HLA-A2 tissue marker and whose urinary bladder, melanoma, head and neck, ovarian, non-small cell lung, esophageal, gastric, synovial sarcoma, or myxoid/round call liposarcoma (MRCLS) tumor has the MAGE-A4 protein expressed. This study will take a subject's T cells and give them a T cell receptor protein that recognizes and attacks the tumors. This study has a substudy component that will investigate the safety and tolerability of MAGE-A4c1032T cell therapy in combination with low dose radiation in up to 10 subjects.