Gastroenteritis Clinical Trial
Official title:
Acute Gastroenteritis: Development of PCR Analysis and Algorithm/Criteria for Fast Clarification of Isolation Indication
Isolation of contagious patients is expensive, requires more caregiver time, most of the
patients perceive isolation as a mental strain and it has been shown that the level of care
and observation is lower than in a normal ward. But isolation of contagious patients is
necessary to protect other patients, hospital staff and relatives to prevent spreading of
infection and, in worst case out-break.
There are different isolation regimes available depending on causative agent and mode of
transmission. A community-acquired acute gastroenteritis (GE) is most often caused by
Norovirus while a hospital-acquired acute GE is often caused by toxin producing Clostridium
difficile. Patients infected with Norovirus or Clostridium difficile have to be isolated in
single rooms with strict contact precautions. Patients infected with acute GE caused by
other pathogens can be isolated in a multi-bed room if there is a private toilet.
However, at the time of arrival to hospital it is not known if the patient is contagious.
The indication of isolation has to be made based of a clinical evaluation in risk of
isolating to few or too many patients.
Aim of the study:
To identify anamnestic, clinical and paraclinical variables that can be used as indicators
of the aetiology of infectious GE, thus giving an indication for isolation.
To clinically evaluate a combined RNA (Norovirus) and DNA (Clostridium difficile) fast PCR
analysis test to identify infectious GE compared to gold standard methods.
n/a
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT01168401 -
Bivalent Norovirus Vaccine Study
|
Phase 1 | |
| Completed |
NCT02541695 -
Characterization of Resistance Against Live-attenuated Diarrhoeagenic E. Coli
|
N/A | |
| Completed |
NCT02473887 -
Flavored Intravenous Ondansetron Administered Orally for the Treatment of Persistent Vomiting
|
Phase 1 | |
| Completed |
NCT01911143 -
A Retrospective, Blinded Validation of a Host-response Based Diagnostics
|
N/A | |
| Not yet recruiting |
NCT01671137 -
Probiotic for the Prevention of Functional Disorders in Childhood
|
N/A | |
| Completed |
NCT01917461 -
Observational, Prospective Clinical Study to Evaluate Biomarkers as Indicators of Acute Bacterial or Viral Infections
|
N/A | |
| Withdrawn |
NCT00691275 -
Efficacy Study of IV Fluids Only vs Ondansetron to Treat Dehydration
|
N/A | |
| Recruiting |
NCT06025695 -
Immunogenicity, Reactogenicity and Safety of GlaxoSmithKline (GSK) Biologicals' Rotarix Porcine Circovirus (PCV)-Free Liquid Compared to Rotarix Liquid Given in 2-doses in Healthy Chinese Infants Starting at Age 6-16 Weeks
|
Phase 3 | |
| Completed |
NCT04463082 -
Non-invasive Assessment of the Current State of Hydration in Children by Ultrasound
|
N/A | |
| Completed |
NCT02497417 -
A Multi-Site Clinical Evaluation of the ARIES Clostridium Difficile Assay in Symptomatic Patients
|
N/A | |
| Active, not recruiting |
NCT03000296 -
Autologous Unselected Hematopoietic Stem Cell Transplantation for Refractory Crohn's Disease
|
N/A | |
| Completed |
NCT01225042 -
The Effect of Probiotics on E. Coli Gastroenteritis
|
N/A | |
| Completed |
NCT01236066 -
Impact of Rotavirus Vaccination on Hospitalisations for Rotavirus Gastroenteritis in Children Aged <5 Years in Australia
|
N/A | |
| Recruiting |
NCT00987519 -
Viral Respiratory and Gastrointestinal Infections in Children Under 6 Years of Age
|
N/A | |
| Terminated |
NCT01357174 -
ROTATEQ™ Post-Marketing Surveillance in the Philippines
|
N/A | |
| Completed |
NCT01033799 -
Effect of the Consumption of a Fermented Milk on Common Infections in Shift-workers
|
N/A | |
| Recruiting |
NCT01363726 -
Surveillance of Rotavirus Gastroenteritis in Children <5 Years
|
N/A | |
| Completed |
NCT00130832 -
Concomitant Use and Staggered Use of Vaccine and Oral Poliovirus (OPV) in Healthy Infants (V260-014)(COMPLETED)
|
Phase 3 | |
| Terminated |
NCT02568189 -
Utility of Ultrasound Assessment of the Inferior Vena Cava in Patients With Sepsis and Dehydration
|
N/A | |
| Terminated |
NCT02165813 -
Oral Nitazoxanide in Acute Gastroenteritis in Australian Indigenous Children
|
Phase 2/Phase 3 |