Transpyloric Feeding for Prevention of Micro-aspiration

Status Active, not recruiting

Clinical Trial Summary

To determine the effect of transpyloric (TP) feeding on microaspiration and lung inflammation in ventilated preterm infants.

Clinical Trial Description

Specific Aim 1): To determine the effect of TP feeding on microaspiration and lung inflammation. Hypothesis: TP feeding will reduce the microaspiration and pulmonary inflammation in ventilated preterm infants. Evaluate markers of microaspiration (pepsin A) and lung inflammation [total cell counts, nuclear factor-kB (NF-kB) activation, tumor necrosis factor-α (TNF-α), IL-1β, IL-6, IL-8, angiopoietin 2 (Ang2), high-mobility group box-1 protein (HMGB1), macrophage migration inhibitory factor (MIF) and interferon-γ (IFN-γ)] in TA samples obtained from preterm ventilated infants with and without TP feeding. Specific Aim 2): To determine the effect of TP feeding on respiratory support. Hypothesis: TP feeding will decrease the respiratory severity score (RSS) [Fraction of inspired oxygen (FiO2) X mean airway pressure (MAP)] and number of infants requiring ventilator support. Evaluate respiratory support in preterm ventilated infants with and without TP feeding. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT03646045
Study type	Observational
Source	Nemours Children's Clinic
Contact
Status	Active, not recruiting
Phase
Start date	November 4, 2016
Completion date	December 15, 2024

View Details

See also
Status	Clinical Trial	Phase
Recruiting	`NCT06025773` - A Study to Compare PK/PD Characteristics and Safety Profiles Between AD-212-A and AD-2121	Phase 1
Recruiting	`NCT06280664` - Efficacy Of Hiatal Closure For GERD
Recruiting	`NCT05359965` - Effect of CPAP on Abnormal Gastroesophageal Reflux and Lung Inflammation in IPF	N/A
Completed	`NCT04202692` - Effect of a Combination Oral Formulation of Hyaluronic Acid, Chondroitin Sulphate and Magnesium Trisilicate in Patients With Gastro-Esophageal Reflux Disease Not Fully Satisfied With Their Treatment	N/A
Recruiting	`NCT06430047` - Efficacy and Safety of EsoDuo®	Phase 4
Completed	`NCT04268719` - Near Focus NBI-Driven Artificial Intelligence for the Diagnosis of Gastro-Oesophageal Reflux Disease
Active, not recruiting	`NCT04614974` - Initiation of Acid Suppression Therapy Prospective Outcomes for Laryngomalacia	Phase 1/Phase 2
Terminated	`NCT05579444` - Systems Biology of Gastrointestinal and Related Diseases
Recruiting	`NCT03868267` - Japanese Upper GI Symptoms Compared With Iranian and Canadian Patients Presenting
Terminated	`NCT04028466` - Effectiveness of Vonoprazan vs Omeprazole as Empiric Therapy for Gastroesophageal Reflux Disease (GERD) Patients Without Alarm Features	Phase 4
Active, not recruiting	`NCT05371717` - Domiciliary Management of Dental Erosion in Patients With GERD With Biomimetic Hydroxyapatite	N/A
Recruiting	`NCT05066594` - Observational Registry of Transoral Incisionless Fundoplication (TIF) for Gastroesophageal Reflux Disease (GERD)
Completed	`NCT03476265` - Lower Esophageal Sphincter (LES) Stimulation in Patients With Ineffective Esophageal Motility	N/A
Completed	`NCT03143608` - GERD Treatment With Transoral Incisionless Fundoplication (TIF) Following Hiatal Hernia Surgery	N/A
Completed	`NCT04436159` - Partial Versus Total Fundoplication in the Surgical Repair of Para-esophageal Hernia.	N/A
Completed	`NCT03258528` - Effect of Right Lateral Position on Ventilated Preterm Neonates	N/A
Active, not recruiting	`NCT04500288` - The Effect of Positional Therapy on Symptoms of Gastroesophageal Reflux Disease: A Prospective Pilot Study	N/A
Completed	`NCT04262648` - Randomized Placebo-controlled Study of L. Reuteri NCIMB 30351 in GI Functional Disorders and Food Allergy in Newborns	N/A
Recruiting	`NCT04846010` - Recovering Damaged Cells for Sequelae Caused by COVID-19, SARS-CoV-2	Phase 1/Phase 2
Active, not recruiting	`NCT03835663` - The Bacterial Composition of the Stomach in Reflux Disease