Clinical Trial Details
— Status: Not yet recruiting
Administrative data
| NCT number |
NCT06015763 |
| Other study ID # |
H.pylori and gastritis |
| Secondary ID |
|
| Status |
Not yet recruiting |
| Phase |
N/A
|
| First received |
|
| Last updated |
|
| Start date |
October 2023 |
| Est. completion date |
December 2024 |
Study information
| Verified date |
August 2023 |
| Source |
Assiut University |
| Contact |
Merna Mawgoud |
| Phone |
01282213004 |
| Email |
mernamawgoud[@]gmail.com |
| Is FDA regulated |
No |
| Health authority |
|
| Study type |
Interventional
|
Clinical Trial Summary
To study the prevelance rate of H.pylori colonization in patients with gastritis.
To correlate the H.pylori colonization with endoscopic finding. To correlate both H.pylori
colonization and endoscopic finding with clinical manifestation.
Description:
Helicobacter pylori is a gram negative microaerophilic spiral bacterium that is usually found
in the stomach and thereby cause infection , which is associated with varying degrees of
damage of superficial and glandular epithelium.
Chronic gastritis is a histological entity that is defined by an inflammatory infiltrate of
lymphoblasma cells, cocsometimes polynuclear neutrophils and by progressive glandular atrophy
of the gastric mucosa,and probably the main cause of chronic inflammation in the gastric
mucosa which is usually caused by H.pylori infection.
In addition to chronic gastritis almost all benign gastroduodenal diseases including peptic
ulcer , mucosa associated lymphoid tissue lymphoma and malignant gastroduodenal
adenocarcinoma occurs due to previous H.pylori infection that is usually started with gastric
precancerous lesion, gastric atrophy , gastric intestinal metaplasia , dysplasia and then
turned to gastric carcinoma.
So the evaluation of H.pylori infection status yo non-infection, past infection, current
infection by endoscopy has therefore become increasingly important.
The Sydney grading system is one of the most important recognised tools yo charactize
histological lesions of chronic gastritis.
The system categorise gastritis according to intensity of mononuclear inflammatory cellular
infiltrate , polymorph activity , atrophy , intestinal metaplasia and H.pylori density into
mild , moderate and severe categories, but up till now there is non-standard histology
reporting formats are still widely used for gastritis and even specialists are often
frustrated by the histological definition that make it difficult to identify candidates for
clinico-endoscopic surveillance.
Therefore the eradication of this bacterium aimed to interrupt the carcinogenesis process and
prevent recurrence of gastritis and peptic ulcer disease.
However despite of the significant researches conducted on H.pylori colonization in gastric
mucosa and its association with endoscopic finding and severity of clinical manifestations,
and its impact on the Egyptian population is still a topic of debate.
Currently, there is no study has definitively determined this relationship in the Egyptian
population despite the high prevalence rate of H.pylori infection
