Gastric Cancer Clinical Trial
Official title:
CKD-702 Plus Irinotecan as a ≥3L Therapy for Gastric and Gastroesophageal Junction Adenocarcinomas Overexpressing EGFR or MET
CKD-702 is a tetravalent bispecific IgG1 targeting hepatocyte growth factor receptor (MET) and epidermal growth factor receptor (EGFR). The investigators will test a hypothesis that CKD-702 may augment the efficacy of biweekly irinotecan as a 3L or later therapy for gastric cancer overexpressing either MET or EGFR.
| Status | Recruiting |
| Enrollment | 40 |
| Est. completion date | December 31, 2025 |
| Est. primary completion date | December 31, 2024 |
| Accepts healthy volunteers | No |
| Gender | All |
| Age group | 19 Years and older |
| Eligibility | Inclusion Criteria: - Failed 2 or more lines of chemotherapy - Tumor overexpressing either MET or EGFR - Measurable lesion Exclusion Criteria: - Prior treatment with anti-MET/EGFR bispecific antibody |
| Country | Name | City | State |
|---|---|---|---|
| Korea, Republic of | National Cancer Center | Goyang | Gyeonggi |
| Lead Sponsor | Collaborator |
|---|---|
| National Cancer Center, Korea |
Korea, Republic of,
| Type | Measure | Description | Time frame | Safety issue |
|---|---|---|---|---|
| Primary | Best objective response rate | RECIST v1.1 | Through study completion, an average of 24 weeks |
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