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Clinical Trial Summary

This is a study of Camrelizumab (SHR-1210) and Apatinb for unresectable Recurrent or metastatic alpha-fetoprotein (AFP)-producing gastric cancer or Gastroesophageal Junction Adenocarcinoma. Camrelizumab combined with Apatinib and standard chemotherapy will be given to treatment-naïve participants; Camrelizumab combined with Apatinib will also be evaluated in participants who have had ≥ 1 line of previous treatment. The primary endpoint is the Overall Response Rate (ORR).


Clinical Trial Description

This study will have 2 cohorts. In Cohort 1, participants who have not received any previous therapy for their disease will receive Camrelizumab and Apatinib in combination with Oxaliplatin and S-1. In Cohort 2, participants who have received at least one prior therapy for their advanced disease will receive Camrelizumab and Apatinib. A Simon two-stage phase II design was used for the sample size Calculation. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT04609176
Study type Interventional
Source Peking University
Contact Xiaotian Zhang
Phone 86-10-88196175
Email zhangxiaotianmed@163.com
Status Recruiting
Phase Phase 2
Start date November 18, 2020
Completion date December 31, 2024

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