Gastric Cancer Clinical Trial
Official title:
Effects of Sarcopenia on Early Postoperative Outcomes in Patients Undergoing Surgical Treatment for Gastric Cancer
We aimed to establish the effects of sarcopenia on postoperative complications among patients undergoing surgical treatment for gastric cancer
Among gastrointestinal disease, gastric cancer is a malignancy which is diagnosed
predominantly in advanced stages, mostly accompanied with malnutrition when diagnosed, has
aggressive behavior with poor oncological outcomes. The only option for curative treatment is
surgical resection in this malignancy; however, the surgical procedure itself causes high
morbidity and mortality rates. Therefore, physicians combine various treatment modalities and
risk assessment to decrease complication and mortality rates.
Sarcopenia is a syndrome characterized by progressive and generalized loss of skeletal muscle
mass and strength with a risk of adverse outcomes such as physical disability, poor quality
of life, and death. For the diagnosis of sarcopenia, using the presence of both low muscle
mass and decreased muscle function (strength or performance) is recommended. Previous studies
showed that colorectal or pancreatic cancer accompanied with sarcopenia has adverse effects
on not only for short term and also for long term outcomes. The majority of studies regarding
gastric cancer was published from Eastern countries owing to their high incidence. There are
few studies from western countries which are mostly retrospective and does not meet the
diagnostic criteria of sarcopenia. In the western population, there is no high-quality
evidence so far regarding the impact of sarcopenia on early outcomes of gastric cancer
surgical treatment.
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