Systematic Review and Meta-analysis of Cereal or Grain Consumption and Gastric Cancer

Gastric Cancer Clinical Trial

— GC  

Official title:

Cereal or Grain Consumption and Gastric Cancer Risk: a Systematic Review and Meta-analysis of Observational Studies

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03419663
• Status: Completed
• Phase: N/A
• First received: January 19, 2018
• Last updated: February 1, 2018
• Start date: September 12, 2017
• Est. completion date: January 10, 2018

Study information

• Verified date: February 2018
• Source: West China Hospital
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

This project involved a systematic literature review of published trials of cereal or grain in relation to the risk of gastric cancer. Data was extracted from the publications on PubMed, EMBASE, Cochrane Library.A traditional meta-analysis, subgroup analysis, and heterogeneity was conducted on the extracted data.

Description:

Investigators searched PubMed, EMBASE, Cochrane Library for studies focusing on cereal or grain in relation to the risk of gastric cancer up to October 2017. Summary odd ratios (OR) and 95% confidence intervals (CI) were calculated by using either random effect models or fixed effect models according to the heterogeneity of included studies. Subgroup analysis, heterogeneity, and publication bias were also performed.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 11
• Est. completion date: January 10, 2018
• Est. primary completion date: December 20, 2017
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: N/A and older

Eligibility

Inclusion Criteria:

• a case-control studies or a cohort study

• investigate the association between cereal or grain intake and GC occurrence

• report an odds ratio (OR) or relative risk (RR) with corresponding 95% confidence intervals (CI)

• provide sufficient data to estimate OR or RR

Exclusion Criteria:

• Non-human studies

• GC mortality-based cohort studies

Related Conditions & MeSH terms

• Gastric Cancer
• Stomach Neoplasms

Intervention

Dietary Supplement:
• cereal or grain consumption
intake of cereal, whole grain, refined grain, and other grain of every day

Locations

Country	Name	City	State
China	West China Hospital, Sichuan University	Chengdu	Sichuan

Sponsors (1)

Lead Sponsor	Collaborator
West China Hospital

Country where clinical trial is conducted

China, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	the relationship between overall cereal consumption and gastric cancer occurance	perform a pooled analysis of included studies with OR through STATA 12.0	up to 2 years
Secondary	the relationship between whole grain and gastric cancer occurance	perform a subgroup analysis to summarize the related OR through STATA 12.0	up to 2 years
Secondary	the relationship between refined grain and gastric cancer occurance	perform a subgroup analysis to summarize the related OR through STATA 12.0	up to 2 years
Secondary	the relationship between other grain and gastric cancer occurance	perform a subgroup analysis to summarize the related OR through STATA 12.0	up to 2 years