Apatinib in Combination With S-1 as Second-Line Treatment in Patients With Advanced Gastric Cancer

Gastric Cancer Clinical Trial

Official title:

Apatinib in Combination With S-1 as Second-Line Treatment in Patients With Advanced Gastric or Gastroesophageal Junction Adenocarcinoma

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT03276156
• Other study ID #: Ahead-G001
• Status: Recruiting
• Phase: Phase 1
• First received: September 6, 2017
• Last updated: September 6, 2017
• Start date: February 23, 2016
• Est. completion date: February 22, 2018

Study information

• Verified date: May 2017
• Source: Zhejiang Cancer Hospital
• Contact: Haijun Zhong
• Phone: 0571-88122058
• Email: ZHJ1712[@]aliyun.com
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The purpose of this study is to determine the maximum tolerated dose (MTD)and safety of Apatinib combined with S-1 as Second-line therapy for patients with advanced gastric or gastroesophageal junction adenocarcinoma.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 12
• Est. completion date: February 22, 2018
• Est. primary completion date: February 22, 2018
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

1. Fully informed consent prior to any specific research procedure.

2. Adult patients, aged =18 years;

3. Imaging test confirmed the progression after first-line treatment of advanced gastric adenocarcinoma or Gastroesophageal Junction Adenocarcinoma.

• S-1 was not used in the first-line treatment

• If patient relapse in 6 months after adjuvant chemotherapy or neoadjuvant chemotherapy, the adjuvant chemotherapy or neoadjuvant chemotherapy was regarded as the first-line treatment.

4. Adjuvant chemotherapy or neoadjuvant chemotherapy was allowed if the first-line treatment started beyond 6 months after the end of previous treatment.

5. During the research ,patient should be willing and be able to follow the process treatment ,follow up and tests.

6. Eastern Cooperative Oncology Group (ECOG) performance status of 0 - 1.

7. Survival expectation = 16 weeks from the planned first dosing .

8. During the 28 days prior to the first dosing, hematological, biochemical and Organ Functions:HB = 9.0 g/dL, ANC = 1.5×109/L,WBC>3×109/L, PLT = 100×109/L, BIL < 1.5×ULN, ALT or AST < 2.5×ULN (or < 5×ULN in patients with liver metastases), Serum Cr = 1.5×ULN;

9. Lesions ,measurable and/or unmeasurable,at least one,can be assessed by imaging during the baseline and follow-up measurement.

• Localized mass in gastric or Gastroesophageal Junction belongs to unmeasurable Lesions.

10. Women, those postmenopausal or of child-bearing age, but the pregnancy test results (serum or urine) within 28 days before treatment is negative, and the results should be confirmed in day 1 of the treatment.

• Postmenopausal women are defined as :woman's menstrual periods have ceased for 1 year or longer after exogenous hormone therapy;

• Women, aged>50years,serum LH and FSH level show a postmenopause;

• Woman has radiation induced ovarian failure,and gone without a period for over 12 consecutive months;

• Woman has chemotherapy-induced menopause and gone without a period for over 12 consecutive months;

• sterilization operation( hysterectomy or bilateral oophorectomy)

Exclusion Criteria:

1. Has participated in another clinical trial in progress.

2. Has received more than one chemotherapy regimens after disease progression(except for those who has receiced adjuvant chemotherapy or neoadjuvant chemotherapy 6 months or longer)

3. Previous therapy with S-1

4. Has received VEGFR inhibitor, such as Sorafenib,Sunitinib .

5. Has another primary tumor,but adequately treated non-melanoma skin cancer , effectively treated carcinoma in situ of cervix and other well handled cancer over 5 years were not covered.

6. Has difficulty in swallowing

7. Has taken experimental drugs within 14 days before randomly assign.( For different drug characteristics, the interval can be longer)

8. History of any chemotherapy, radiotherapy,the last administration should finish within 3 weeks prior to trial first drug administration( For different drug characteristics, the interval can be longer). If steady dose of diphosphate or denosumab is necessary for the treatment of bone metastases,the administration should start 3-4weeks prior to the study .

9. Patients with poor-controlled arterial hypertension (systolic blood pressure > 140 mmHg or diastolic blood pressure > 90 mm Hg) despite standard medical management; Coronary heart disease greater than Class I, arrhythmia greater than Class I (including QT interval prolongation, for man > 450 ms, for woman > 470 ms), and cardiac dysfunction greater than Class I;

10. Has persistent toxicity (exclude alopecia )of previous treatment ,CTCAE>1.

11. Has intestinal obstruction or upper gastrointestinal hemorrhage(CTCAE 3 or 4) within 4 weeks prior to randomly assign.

12. Abnormal coagulation function (INR > 1.5×ULN, APTT > 1.5×ULN), with tendency of bleed;

13. Has symptom of brain metastases and the tendency out of control,but imaging confirmed is not required.If steady dose of Glucocorticoid is necessary for the treatment,the administration should be started >4weeks prior to the study . Patients with spinal cord compression received definite treatment and the situation had been proven stable in 28days .

14. Has surgery within 2 weeks prior to the study. Eligible patients should recovered from any major surgery.

15. Subjects that are unable to swallow tablets, chronic diarrhea ,or intestinal obstruction;

16. Subjects with a clear tendency of gastrointestinal bleeding;

17. Pregnant or lactating women;

18. Other conditions regimented at investigators' discretion.

Related Conditions & MeSH terms

• Gastric Cancer
• Stomach Neoplasms

Intervention

Drug:
• Apatinib plus S-1
Drug:Apatinib (425 mg/d) + S-1 (80mg to 120 mg);Drug:Apatinib (500 mg/d) + S-1 (80mg to 120 mg);Drug:Apatinib (675mg/d) + S-1 (80mg to 120 mg);Drug:Apatinib (750 mg/d) + S-1 (80mg to 120 mg);

Locations

Country	Name	City	State
China	Zhejiang Cancer Hospital	Hangzhou	Zhejiang

Sponsors (2)

Lead Sponsor	Collaborator
Zhejiang Cancer Hospital	Jiangsu HengRui Medicine Co., Ltd.

Country where clinical trial is conducted

China, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Progression Free Survival(PFS)		Event driven, an expected average of 4 months
Primary	Incidence of adverse events		An expected average of 4 months
Secondary	Overall survival(OS)		An expected average of 12months
Secondary	Disease control rate(DCR)		An expected average of 4 months
Secondary	Objective response rate(ORR)		An expected average of 4 months
Secondary	Quality of life(QoL)		An expected average of 12 months