Gastric Cancer Clinical Trial
Official title:
Postgenome-based Systemic Discovery of Strong Biomarkers Predict Gastric Cancer Chemotherapy Response
- discovery and validation of biomarker predicting gastric cancer chemotherapy response - Analysis for expression level of mRNA using Next generation sequencing in gastric cancer tissue by chemotherapy response - Analysis for expression level of miRNA using Next generation sequencing in gastric cancer tissue and blood by chemotherapy response - Validation of mRNA and miRNA using qRT-PCR in multiple independent cohort - Biological biomarkers-clinical factor combined prediction model of gastric cancer chemotherapy response
- discovery and validation of biomarker predicting gastric cancer chemotherapy response - Analysis for expression level of mRNA in fresh frozen gastric cancer tissue by chemotherapy response (A) method of mRNA expression measurement: RNA sequencing (B) study group Palliative chemotherapy (inoperable patients) - institutional primary Chemotherapy regimen (XP or Xelox) 1. response group 2. progression group Post-OP adjuvant chemotherapy - institutional primary Chemotherapy regimen 1. complete response group 2. non-responder group 1. and 2) groups: age, sex, regimen matched - Analysis for expression level of miRNA using Next generation sequencing in gastric cancer tissue and blood by chemotherapy response (A) method of mRNA expression measurement: RNA sequencing (B) study group - the same patients in mRNA sequencing - Validation of mRNA and miRNA in multiple independent cohort method of measurement of RNA expression: qRT-PCR - Biological biomarkers-clinical factor combined prediction model of gastric cancer chemotherapy response combination of biologic biomarker and clinical factors to predict the chemotherapy response in gastric cancer ;
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