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Clinical Trial Summary

The goal of this study is to evaluate the safety, tolerability, pharmacokinetics (PK), immunogenicity, and anti-tumor activities of cadonilimab in combination with Ivonescimab plus chemotherapy as first-line therapy in adult subjects with HER2 negative态advanced or metastatic gastric (G) or gastroesophageal junction (GEJ) cancer.


Clinical Trial Description

The study consists of a dose escalation and expansion phase to determine the recommended Phase 2 dose (RP2D) for AK104 in combination with AK112 and SOX/XELOX, and a dose confirmation phase which will further characterize the treatment of AK104 in combination at the RP2D. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT06196697
Study type Interventional
Source Harbin Medical University
Contact yanqiao zhang, phD
Phone +86 138 4512 0210
Email yanqiaozhang@126.com
Status Not yet recruiting
Phase Phase 2
Start date January 2024
Completion date March 2027

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