Combination of Capmatinib + Spartalizumab in Advanced Oesogastric

Clinical Trial Summary

Immunotherapy with anti-PD1 antibodies provides encouraging results on a subset of patients. Capmatinib, a MET inhibitor, has shown an imunomodulatory effect and a synergy with spartalizumab a PD-1 inhibitor. The purpose of this phase II trial is to evaluate the efficacy and safety of the combination of capmatinib + spartalizumab in adult patients with advanced oesogastric adenocarcinoma.

See also
Status	Clinical Trial	Phase
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Completed	`NCT03196232` - Epacadostat and Pembrolizumab in Treating Patients With Metastatic or Unresectable Gastroesophageal Junction or Gastric Cancer	Phase 2
Recruiting	`NCT04047953` - Paclitaxel (Albumin-bound) Combined With Oxaliplatin and S-1 Conversion Therapy for Gastric Adenocarcinoma	N/A
Completed	`NCT02891447` - Heated Mitomycin and Cisplatin During Surgery in Treating Patients With Stomach or Gastroesophageal Cancer	Phase 2
Completed	`NCT02864381` - Study to Evaluate the Efficacy and Safety of Andecaliximab Combined With Nivolumab Versus Nivolumab Alone in Adults With Unresectable or Recurrent Gastric or Gastroesophageal Junction Adenocarcinoma	Phase 2
Terminated	`NCT04032704` - A Study of Ladiratuzumab Vedotin in Advanced Solid Tumors	Phase 2
Terminated	`NCT04604132` - Derazantinib Alone or in Combination With Paclitaxel, Ramucirumab or Atezolizumab in Gastric Adenocarcinoma	Phase 1/Phase 2
Completed	`NCT02830594` - Pembrolizumab and Palliative Radiation Therapy in Treating Patients With Metastatic Esophagus, Stomach, or Gastroesophageal Junction Cancer	Phase 2
Recruiting	`NCT06038578` - A Study of TRK-950 When Used in Combination With Ramucirumab and Paclitaxel in Patients With Gastric Cancer	Phase 2
Terminated	`NCT04099277` - A Study of LY3435151 in Participants With Solid Tumors	Phase 1

NCT number	NCT05135845
Study type	Interventional
Source	Assistance Publique - Hôpitaux de Paris
Contact
Status	Suspended
Phase	Phase 2
Start date	March 22, 2022
Completion date	October 2025

Combination of Capmatinib + Spartalizumab in Advanced Oesogastric Adenocarcinoma — METIMGAST

Clinical Trial Summary

Clinical Trial Description

Study Design

Related Conditions & MeSH terms