Comparison of the Gastric Acid Suppressive Effects of Esomeprazole and Generic Omeprazole

Gastric Acid Clinical Trial

Official title:
Comparison of the Gastric Acid Suppressive Effects of Esomeprazole and Generic Omeprazole

Status Terminated

Clinical Trial Summary

Proton pump inhibitors (PPI) are used to decrease stomach acid secretion. A generic form of omeprazole, one of the PPIs, is on the market. With cheaper than brand name PPIs, it is unclear whether generic omeprazole is as effective clinically. This study compares generic omeprazole with half-dose esomeprazole, the strongest brand name PPI. The half-dose esomeprazole is in fact cheaper than generic omeprazole. Healthy volunteers will take each medication in turn for 7 days and their stomach acid will be measured while taking each medication. We hypothesize that half-dose esomeprazole is better at suppressing stomach acid than generic omeprazole.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Gastric Acid

Clinical Trial Details

NCT number	NCT00542347
Study type	Interventional
Source	Queen's University
Contact
Status	Terminated
Phase	Phase 3
Start date	September 2007
Completion date	July 2018

View Details

See also
	Status	Clinical Trial	Phase
	Completed	`NCT00765206` - A Pharmacodynamic Study Comparing Zegerid® and Prilosec OTC® (Study CL2008-02)(P07814)(COMPLETED)	Phase 3
	Completed	`NCT00674115` - A Pharmacodynamic Study Comparing Zegerid® and Prilosec OTC® (CL2007-17 )(P07813)(COMPLETED)	Phase 3