Retinal Ganglion Cell Layer in Patients With Intracerebral Processes

Ganglion Cells Clinical Trial

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02407886
• Other study ID #: 2014-0649
• Status: Completed
• Phase: N/A
• First received: March 5, 2015
• Last updated: May 24, 2017
• Start date: March 2015
• Est. completion date: May 2016

Study information

• Verified date: May 2017
• Source: University of Zurich
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Transsynaptic degeneration of the retinogeniculate pathways is well documented to occur in nonhuman primates when the cerebral lesion occurs even during adulthood. In case of humans, retrograde transsynaptic degeneration of the retinogeniculate pathways has been shown to occur following prenatal or perinatal lesions, but its occurrence after cerebral lesions in adults is considerable rare. It is, however, well established that retrograde transsynaptic degeneration affects other neural systems in humans even when the injury occurs during adulthood. Some histopathological evidence points to the possibility of transsynaptic degeneration of the retinogeniculate pathway in humans even when the lesion occurs in adults, but the clinical significance is unknown.'

Purpose:

To measure the retinal ganglion cell layer (GCL) in patients with visual field defects due to intracerebral processes. To correlate GCL with the localization and type of intracerebral lesion.

To compare the GCL with the retinal nerve fibre layer (RNFL) to investigate, which of the 2 parameters is more sensitive to show retinal layer abnormalities.

To correlate GCL with visual field defects and electrophysiological parameters.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 20
• Est. completion date: May 2016
• Est. primary completion date: December 2015
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years to 60 Years

Eligibility

Inclusion Criteria:

• adult patients with intracerebral lesions within the central visual tract

• associated visual field defects

• investigations (OCT, ERG) possible

Exclusion Criteria:

• lesions within the optic nerve without extension in the optic tract

• neurological disease

• optic disc anomalies: glaucoma, nystagmus, high myopia

Related Conditions & MeSH terms

• Ganglion Cells
• Ganglion Cysts

Locations

Country	Name	City	State
Switzerland	University Hospital Zurich	Zurich

Sponsors (1)

Lead Sponsor	Collaborator
University of Zurich

Country where clinical trial is conducted

Switzerland, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Ganglion cell thickness		measurements will be taken at a minimum of 4 weeks after the inital diagnosis