PRF+1% MF for Class II Mandibular Furcation Defects

Status Completed

Clinical Trial Summary

The aim of the present trial is to evaluate the efficacy of PRF with 1% MF in treatment of mandibular class II furcation defects and its comparison to PRF and access therapy alone.

Clinical Trial Description

Background: For improving efﬁcacy and outcomes of regenerative therapy for furcation defects, various materials has been investigated in addition to access therapy. Platelet-rich fibrin (PRF) having concentrated growth factors and cytokines and Metformin (MF), an efficacious member of biguanide group are known to enhance periodontal regeneration. The aim of the present trial is to evaluate the efficacy of PRF with 1% MF in treatment of mandibular class II furcation defects and its comparison to PRF and access therapy alone.

Methods: This randomized trial was conducted on 75 patients with mandibular class II furcation defects. Defects were surgically treated with either access therapy alone (Group 1), access therapy+PRF (Group 2), and access therapy+ PRF+1% MF (Group 3). Clinical parameters like probing depth (PD), relative clinical attachment level {vertical (RVCAL) and horizontal (RHCAL)}, modified sulcus bleeding index (mSBI) and site specific plaque index (PI) were evaluated at baseline and 9 months post-operatively. Radiological assessment of bone defect fill was done at baseline and 9 months. ;

Study Design

Related Conditions & MeSH terms

Furcation Defects

Clinical Trial Details

NCT number	NCT03207698
Study type	Interventional
Source	Government Dental College and Research Institute, Bangalore
Contact
Status	Completed
Phase	Phase 2/Phase 3
Start date	September 2015
Completion date	May 2016

View Details

See also
Status	Clinical Trial	Phase
Not yet recruiting	`NCT04851548` - Evaluate the Effect of Hyaluronic Acid in the Treatment of Furcation Involvement	N/A
Recruiting	`NCT06025955` - Evaluation of Outcomes of Minimally Invasive Non- Surgical Versus Surgical Therapy in Furcation Involvement.	N/A
Not yet recruiting	`NCT05721313` - Vital Root Amputation in Molars With Advanced Periodontal Furcation Involvement: a Preliminary Study	N/A
Not yet recruiting	`NCT05481580` - Restorations and Furcation Involvement on Molars
Recruiting	`NCT06060340` - Clinical and Radiographic Outcomes of Class II Furcation Defects Management Using Propolis: A Case Series	Early Phase 1
Recruiting	`NCT05541614` - Flapless Application of Enamel Matrix Derivative in Class II Mandibular Furcation Defects	N/A
Terminated	`NCT04059458` - Mandibular Furcation III Regeneration (FURC-III-REGEN)	Phase 4
Withdrawn	`NCT03917030` - Osteoplasty in Conjunction With Surgical Treatment of Mandibular Grade II Furcation Defects	N/A
Terminated	`NCT04059445` - Mandibular Furcation II Regeneration	Phase 4
Withdrawn	`NCT04017429` - Osteoplasty in Conjunction With Surgical Treatment of Mandibular Grade III Furcation Defects (FURC-III-OST)	N/A
Completed	`NCT02369250` - Rosuvastatin Gel With 1:1 Mixture of Platelet-rich Fibrin and Bone Graft in Mandibular Degree II Furcation Defects	Phase 4
Not yet recruiting	`NCT06116487` - MRI as Alternative to CBCT for the Assessment of Furcation Involvement in Molars
Completed	`NCT03578744` - Comparison of Platelet Rich Fibrin as Graft & Membrane Vs Hyaluronic Acid & Amniotic Membrane in the Treatment of Interradicular Defects	N/A
Recruiting	`NCT03180658` - Concentrated Growth Factors in Regenerative Therapy in Furcation Involvements in Humans	N/A
Active, not recruiting	`NCT05259982` - Vital Root-resective Therapy in Furcation-involved Maxillary Molars	N/A
Active, not recruiting	`NCT02132806` - Piezosurgery in the Treatment of Class II Furcation Involvement	N/A
Completed	`NCT02102360` - Conventional or Minimally Invasive Surgical Technique for the Treatment of Furcation Defects Using Enamel Matrix Derivative and Anorganic Bovine Bone - a Randomized Controlled Clinical Trial.	Phase 4
Not yet recruiting	`NCT06270303` - Use of a Bone Substitute Material in the Surgical Therapy of Furcation Defects	N/A
Completed	`NCT03354182` - Surgical Treatment of Mandibular Furcations Using a Xenograft With/Without a Collagen Membrane	N/A
Completed	`NCT04842188` - Furcation Treatment With L-PRF and aPDT	N/A