Furcation Defects Clinical Trial
Official title:
Platelet Rich Fibrin Combined With 1% Alendronate Gel in Treatment of Mandibular Degree II Furcation Defects: A Randomized Controlled Clinical Trial
The present study was designed to evaluate the combined efficacy of PRF and 1% ALN in the treatment of mandibular degree II furcation defects when compared with PRF and open flap debridement (OFD) alone.
Background: Various regenerative materials have been introduced and tested in the treatment
of furcation defects. Platelet-rich fibrin (PRF) is a reservoir of growth factors and
cytokines which are the key factors for regeneration of bone and maturation of the soft
tissue. Alendronate (ALN), a potent member of bisphosphonate group is known to promote
tissue regeneration by inhibiting osteoclastic bone resorption and promoting
osteoblastogenesis. The present study was designed to evaluate the combined efficacy of PRF
and 1% ALN in the treatment of mandibular degree II furcation defects when compared with PRF
and open flap debridement (OFD) alone.
Methods: Seventy two mandibular furcation defects were treated with either OFD alone (Group
1), OFD with PRF (Group 2), and OFD with PRF+1% ALN (Group 3). Clinical parameters; site
specific plaque index (PI), modified sulcus bleeding index (mSBI), probing depth (PD),
relative vertical attachment level (RVAL) and relative horizontal attachment level (RHAL),
intrabony defect depth (IBD) were recorded at baseline before surgery and 9 months
post-operatively. Percentage radiographic defect fill was evaluated at baseline and 9
months.
;
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Treatment
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