Polymorphism of the Cytochrome P450-system in Renal Transplants

Function of Renal Transplant Clinical Trial

Official title: Polymorphism of the Cytochrome P450-system and the MDR-system in Renal Transplants Receiving the Immunosuppressive Drugs Tacrolimus, Sirolimus, Everolimus or Cyclosporine A

Status Completed

Clinical Trial Summary

In this study the researchers want to investigate genetic polymorphisms of cytochrome 450 enzymes and the multiple drug resistance (MDR) gene in renal transplant patients to look for differences in dosing of immunosuppressive drugs (tacrolimus, sirolimus, everolimus, cyclosporine A).

All patients who receive one of these drugs can be included and drug blood trough levels, dosing and genetics are compared.

Clinical Trial Description

Primary endpoint is the

1. serum creatinine in patients with and without polymorphysms

2. rate of rejections in patients with and without polymorphysms ;

Study Design

Time Perspective: Retrospective

Related Conditions & MeSH terms

• Function of Renal Transplant

• NCT number: NCT00223054
• Study type: Observational
• Source: University of Schleswig-Holstein
• Status: Completed
• Phase: Phase 4
• Start date: March 2005
• Completion date: October 2006