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Clinical Trial Details — Status: Completed

Administrative data

NCT number NCT01795001
Other study ID # S55133
Secondary ID
Status Completed
Phase
First received
Last updated
Start date October 2012
Est. completion date September 13, 2017

Study information

Verified date May 2018
Source Universitaire Ziekenhuizen Leuven
Contact n/a
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

The purpose of this study is to gain further insights into the molecular pathogenesis of Fuchs' endothelial corneal dystrophy (FECD), to identify targets for potential specific drug therapy.


Recruitment information / eligibility

Status Completed
Enrollment 460
Est. completion date September 13, 2017
Est. primary completion date September 13, 2017
Accepts healthy volunteers No
Gender All
Age group N/A and older
Eligibility Inclusion Criteria:

- FECD

- normal corneas (including enucleations for uveal melanoma)

- non-FECD oedematous corneas

Exclusion Criteria:

- prior irradiation therapy for uveal melanoma

- corneal extension of uveal melanoma

Study Design


Related Conditions & MeSH terms


Intervention

Other:
No intervention


Locations

Country Name City State
Belgium Department of Translational Cell and Tissue Research - campus Sint-Raf - UZ Leuven Leuven

Sponsors (4)

Lead Sponsor Collaborator
Universitaire Ziekenhuizen Leuven Fund for Scientific Research, Flanders, Belgium, Funds for Research in Ophthalmology, Belgium, Mieke Perdaens fund for Eye Research

Country where clinical trial is conducted

Belgium, 

Outcome

Type Measure Description Time frame Safety issue
Primary cytokine levels dosage of cytokine levels in aqueous humour (exploratory, non-interventional study) at time of prelevation (once, no intervention)
Primary gene expression levels microarray expression analysis, reverse transcriptase - quantitative polymerase chain reaction (RT-qPCR), RNA-sequencing (exploratory, non-interventional study) at time of prelevation (once, no intervention)
Primary protein content immunohistochemistry and immunofluorescence at time of prelevation (once, no intervention)
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