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NCT04359576 Clinical Trial

Frozen-thawed Embryo Transfers and Hormone Substitution on Thrombotic Risk Markers

Frozen Embryo Transfer Clinical Trial

— TromboFET  

Official title:
Impact of Frozen-thawed Embryo Transfers and Hormone Substitution on Thrombotic Risk Markers

Clinical Trial Details — Status: Active, not recruiting

Administrative data
NCT number NCT04359576
Other study ID # TromboFET
Secondary ID
Status Active, not recruiting
Phase
First received
Last updated
Start date August 1, 2019
Est. completion date December 2024

Study information
Verified date April 2021
Source Horsens Hospital
Contact n/a
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

The study focus on the impact of estrogen/progesterone substitution during artificial cycle frozen embryo transfer (AC-FET) in women undertaking assisted reproductive technology treatment (ART).

Description:

The aim is to investigate whether the coagulation is activated in women undergoing estrogen/progesterone substitution during artificial cycle frozen embryo transfer (AC-FET) in assisted reproductive technology treatment (ART). An activation of the coagulation might induce an increased thromboembolic risk in these women. Thus, the present study may lead to improvement of the current treatment protocol for women receiving AC-FET and ultimately prevent thromboembolic complications for woman in fertility treatment.

Recruitment information / eligibility
Status Active, not recruiting
Enrollment 50
Est. completion date December 2024
Est. primary completion date March 2022
Accepts healthy volunteers
Gender Female
Age group 18 Years to 50 Years
Eligibility Inclusion Criteria: - Women receiving FET with or without estrogen/progesterone substitution Exclusion Criteria: - Known bleeding disorder - Indication for thromboprophylaxis during ART treatment - Treatment with anti-platelet medication including non-steroid-anti-inflammatory drugs (NSAIDs) within the last week - Donor recipients

Study Design

Related Conditions & MeSH terms

Intervention

Diagnostic Test:
• Primary and secondary hemostasis
Focus on platelet aggregation, primary and secondary hemostasis parameters

Locations
Country Name City State
Denmark Horsens Regional Hospital Horsens

Sponsors (2)
Lead Sponsor Collaborator
Horsens Hospital Aarhus University Hospital

Country where clinical trial is conducted

Denmark, 

Outcome
Type Measure Description Time frame Safety issue
Primary coagulation Primary and secondary hemostasis parameters 1 year
See also
  Status Clinical Trial Phase
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Terminated NCT04092829 - Impact of Corpus Luteum Presence or Absence in the Incidence of Preeclampsia After Frozen Embryo Transfer N/A
Withdrawn NCT04954196 - Benefit of Amlodipine in HRT Cycle for Frozen Embryo Transfer in the Correction of Uterine Pulsatility Index Phase 2
Completed NCT04758871 - Oral Versus Vaginal Progesterone for Luteal Phase Supplementation in Frozen Embryo Transfer Cycles Phase 4
Completed NCT03740568 - Effect of Intervention on Progesterone Levels Before Euploid Embryo Transfer in Pregnancy Outcomes. N/A
Completed NCT04013438 - Luteal Phase Support During Frozen Embryo Transfer Cycle Phase 3
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Recruiting NCT03976544 - Natural Cycle Versus Hormone Replacement Therapy Cycle for a Frozen-thawed Embryo Transfer in PGT Patients Phase 4
Recruiting NCT04804020 - Natural Cycle vs. Modified Natural Cycle vs. Artificial Cycle Protocol for Endometrial Preparation. N/A
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Terminated NCT05802303 - Estrogen (Gel)Transdermal vs Oral Estrogen for Endometrial Preparation N/A
Recruiting NCT05716139 - Natural Cycle vs Programmed Cycle Frozen Embryo Transfer N/A
Enrolling by invitation NCT04455191 - Comparison of Thawing Embryos in Advance and on the Day of Transfer on Pregnancy Outcomes in FET Cycle N/A
Completed NCT03660007 - Incidence of Pulmonary and Venous Thromboembolism in IVF Pregnancies After Fresh and Frozen Embryo Transfer
Not yet recruiting NCT04247204 - Assessment of Endometrial and Sub-endometrial Vascularity Before and After PRP Infusion in Frozen Embryo Transfer Cycles N/A
Recruiting NCT06307184 - Assessing the Convenience of Natural Proliferative Phase Frozen Embryo Transfer
Recruiting NCT05739019 - The Impact of Past Coronavirus Disease 19 (COVID-19) Infection on the Live Birth Rates of Frozen Embryo Transfer Cycles
Recruiting NCT06239376 - Artificial Cycle With or Without GnRH Agonist Pre-treatment for Frozen Embryo Transfer in Adenomyosis Patients N/A
Completed NCT01943812 - Substituted Frozen Embryo Transfer Cycles With GnRH-agonist Supplementation Phase 4
Active, not recruiting NCT05555121 - Rescue Progesterone Supplementation During Frozen Embryo Transfer Phase 2