Free Flap Reconstruction Clinical Trial
Official title:
The Effect of Dexmedetomidine as an Adjuvant for Lower Limb Nerve Blocks Following Oromaxillofacial Reconstruction
Peripheral nerve block has been recommended as the technique for postoperative pain
management because it provides equivalent analgesia but with fewer adverse effects than
either systemic or epidural analgesia.
The use of clonidine, a partial α2 adrenoceptor agonist, has been reported to prolong the
duration and analgesia in peripheral nerve blockade. Dexmedetomidine is a more selective and
shorter-acting α2 adrenergic receptor.However, its use in femoral and common peroneal nerve
blocks has not been described.
In this study, we investigated the effect of adding dexmedetomidine as additive in femoral
and common peroneal nerve blocks for postoperative analgesia.
Patients, diagnosed as oromaxillofacial tumor and undergoing elective free fibular or
anterolateral thigh flap reconstruction, were divided into two groups in a randomized,
double-blind fashion. In Group Ropivacaine (Group R), nerve blocks were administered with
0.3% ropivacaine. In Group Ropivacaine + Dexmedetomidine (Group RD), nerve blocks were
administered with 0.3% ropivacaine and 50 μg dexmedetomidine.The primary endpoints were the
onset time and duration of sensory blocks. The secondary endpoints were heart rate, blood
pressure, SpO2, sedation level, the duration of motor blocks.
Peripheral nerve block has been recommended as the technique for postoperative pain
management because it provides equivalent analgesia but with fewer adverse effects than
either systemic or epidural analgesia.
The use of clonidine, a partial α2 adrenoceptor agonist, has been reported to prolong the
duration and analgesia in peripheral nerve blockade. Dexmedetomidine is a more selective and
shorter-acting α2 adrenergic receptor.However, its use in femoral and common peroneal nerve
blocks has not been described.
In this study, we investigated the effect of adding dexmedetomidine as additive in femoral
and common peroneal nerve blocks for postoperative analgesia.
Patients, diagnosed as oromaxillofacial tumor and undergoing elective free fibular or
anterolateral thigh flap reconstruction, were divided into two groups in a randomized,
double-blind fashion. For patients with free fibular flaps harvested, femoral nerve block
and common peroneal nerve with ropivacaine were administered. For patients with
anterolateral thigh flaps harvested, femoral nerve block with ropivacaine was
administered.In Group R, nerve blocks were administered with 0.3% ropivacaine. In Group RD,
nerve blocks were administered with 0.3% ropivacaine and 50 μg dexmedetomidine.The primary
endpoints were the onset time and duration of sensory blocks. The secondary endpoints were
heart rate, blood pressure, pulse oxygen saturation (SpO2), sedation level, the duration of
motor blocks.
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| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
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|