Frailty Clinical Trial
Official title:
Frailty Status and Increased Risk for Falls: The Role of Anticholinergic Burden
We hypothesized that the use of anticholinergic medications may precipitate falls differently by frailty status in older adults. Community-dwelling older subjects admitted to the Geriatrics Outpatient Clinic prospectively enter into the study. Frailty status is defined according to the Physical Frailty Phenotype. The drugs are categorized according to the ACB scale
Previous studies have found that the use of drugs with anticholinergic properties relate to
increased prevalence of falls in older women and men. Frailty is associated with serious
health outcomes including falls, hip fractures, and death. Frailty can be a relevant target
to investigate its association with the risk of falls among the users of drugs with
anticholinergic properties. A recent evidence suggests that the interaction between being
frail and adverse outcomes in older adults receiving polypharmacy or centrally acting drugs
is complex and not straightforward across all frailty phenotypes.
We classify the participants frail if they met at least three of five criteria, while those
having one or two criteria were pre-frail, and others were non-frail. We determine the
anticholinergic burden by using the Anticholinergic Cognitive Burden (ACB) Scale developed by
Boustani et al.
;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Active, not recruiting |
NCT04992286 -
Detection, Evaluation and Monitoring of Frailties in the Elderly (FRAGING)
|
N/A | |
| Enrolling by invitation |
NCT05009706 -
Self-care in Older Frail Persons With Heart Failure Intervention
|
N/A | |
| Completed |
NCT05529147 -
The Effects of Medication Induced Blood Pressure Reduction on Cerebral Hemodynamics in Hypertensive Frail Elderly
|
||
| Recruiting |
NCT04444544 -
Quality of Life and High-Risk Abdominal Cancer Surgery
|
||
| Completed |
NCT04061785 -
Impact of Skills Acquired Through Judo Training on Risk Factors for Falling in Elderly Men and Women
|
N/A | |
| Completed |
NCT04140890 -
Supporting Habit Formation to Attenuate Prefrailty in Elders: Pilot Study
|
N/A | |
| Recruiting |
NCT03141866 -
Seated Physical Activity in Ageing
|
N/A | |
| Completed |
NCT04888884 -
Loss of Independence - a Rapid Alternative to Frailty Screening in a Swedish ED Setting
|
||
| Recruiting |
NCT04145726 -
Frailty In Thoracic Surgery for Esophageal Cancer
|
||
| Recruiting |
NCT04717869 -
Identifying Modifiable PAtient Centered Therapeutics (IMPACT) Frailty
|
||
| Not yet recruiting |
NCT06022666 -
PATH Program for for Severely Frail or Cognitively Impaired Patients Scheduled for Cancer Surgery.
|
N/A | |
| Not yet recruiting |
NCT04514536 -
Evaluation of a Health Monitoring Platform for Elderly in Home Care Context
|
N/A | |
| Completed |
NCT01126723 -
Effects of Tai Chi on Frailty in Elderly Adults
|
N/A | |
| Completed |
NCT00183040 -
HORMA: Hormonal Regulators of Muscle and Metabolism in Aging
|
Phase 2 | |
| Active, not recruiting |
NCT05961319 -
Smart Home Technologies for Assessing and Monitoring Frailty in Older Adults
|
||
| Enrolling by invitation |
NCT05047731 -
Antihypertensive Deprescribing in Long-term Care
|
N/A | |
| Completed |
NCT04956705 -
Vitamin D and Calcium Supplementation at Danish Nursing Homes
|
N/A | |
| Recruiting |
NCT03824106 -
Frailty Rehabilitation
|
Phase 4 | |
| Recruiting |
NCT04518423 -
Prevalence, Determinants and Natural History of Frailty and Pre-frailty in Elderly People
|
||
| Completed |
NCT04087343 -
Strength on Wheels: A Meal Delivery and Exercise Intervention for Homebound Older Adults
|
N/A |