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Clinical Trial Summary

Etomidate is an unique drug used for induction of general anesthesia and sedation. Adrenal cortical inhibition by etomidate has received much attention. However wether the circadian rhythm and pulse secretion pattern of cortisol in children are the same as that in adults is not known. Moreover, the effect of etomidate on circadian rhythm changes and clinical outcomes has never been carefully studied in children undergoing surgery. Our hypothesis is that etomidate can relieve the changes of circadian rhythm of salivary cortisol in children for 24-48 hours,and this does not make clinical outcomes worse postoperatively.


Clinical Trial Description

- Sample size assessment: Using formula to calculate the total number is 30.

- Statistical analysis: ANOVA

- Reporting for adverse events: During the period of study, if there is any severe adverse event happening, such as severe infection, severe low cortisol concentration threatening the patient's life we will stop the trial. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT02013986
Study type Interventional
Source Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Contact Chen yijun
Phone 86-21-13764206966
Status Unknown status
Phase Phase 4
Start date September 2013
Completion date August 2014

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