Fracture Dislocation Clinical Trial
Official title:
Randomized, Double Blind Trial of Study of PLGA-Mg Material in Clinical Orthopedics
The different proportion samples of PLGA-Mg were made in this study. Then, they would be placed in the femoral condyle of the New Zealand rabbits. The appropriate proportion of PLGA-Mg is obtained after the experiment, which will be used to make the plate or screw to fix the fragments. Then, the clinical role for bone will be assessed.
The deposition of calcium could be facilitated by the increase of magnesium, which played an
important role in fracture union. However, its degradation may be completed before the
fracture line was disappeared. In addition, the hydrogen may be released during degradation.
Thus, its clinical popularization was limited.
As a new polymer material, poly lactic-co-glycolic acid (PLGA) has been widely used
clinically. The hydrolytic production of PLGA was acidic, which could neutralize the
alkalinity of production degraded from magnesium. In addition, it was a long time before the
total accomplishment of degradation of PLGA, which may postpone the degradation of
magnesium.
The different proportion samples of PLGA-Mg were made in this study. Their physical and
chemical properties were analyzed to estimate its safety of implantation. Then, they would
be placed in the femoral condyle of the New Zealand rabbits. The osteogenesis and
complication of samples are examined to select an appropriate proportion of PLGA-Mg is
obtained. Then, the PLGA-Mg material will be used to fix the fracture of human as a
fixation. The review of the patients will be conducted to assess its clinical role.
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