Clinical Trials Logo
  1. Home
  2. Food Hypersensitivity
  3. NCT02350660
  4. Details
NCT02350660 Clinical Trial

Oral Immunotherapy for Peanut and Mammalian Meat Allergies

Food Hypersensitivity Clinical Trial

Official title:
Oral Immunotherapy for Peanut and Mammalian Meat Allergies

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT02350660
Other study ID # 15098
Secondary ID
Status Completed
Phase N/A
First received
Last updated
Start date March 2012
Est. completion date June 2015

Study information
Verified date November 2020
Source University of Virginia
Contact n/a
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

Pilot study to assess the effect of oral immunotherapy on specific Immunoglobulin E (IgE) levels and antigen consumption in two distinct food allergies.

Description:

In subjects with mammalian meat allergy, the effect of daily oral cow's milk on immune parameters and desensitization will be assessed. Similarly, in subjects with a peanut allergy the effects of low dose peanut flour will be assessed and comparisons between two distinct food allergies.

Recruitment information / eligibility
Status Completed
Enrollment 24
Est. completion date June 2015
Est. primary completion date September 2014
Accepts healthy volunteers Accepts Healthy Volunteers
Gender All
Age group 4 Years to 80 Years
Eligibility Inclusion Criteria: - Presence or absence of specific IgE to alpha-gal or peanut Exclusion Criteria: - History of severe anaphylaxis - allergy to cow's milk protein

Study Design

Related Conditions & MeSH terms

Intervention

Dietary Supplement:
• cow's milk
daily consumption of cow's milk
• peanut powder
peanut oral immunotherapy

Locations
Country Name City State
United States University of Virginia Charlottesville Virginia

Sponsors (1)
Lead Sponsor Collaborator
University of Virginia

Country where clinical trial is conducted

United States, 

Outcome
Type Measure Description Time frame Safety issue
Primary The Level of Allergen Consumed Post-oral Immunotherapy consumption of cow's milk or peanut flour at open challenge. This is a single time-point assessment; not measured repeatedly. Following 36 months of maintenance oral immunotherapy, participants completed an open challenge at month 37
See also
  Status Clinical Trial Phase
Completed NCT01904604 - Peanut Epicutaneous Phase II Immunotherapy Clinical Trial Phase 2
Enrolling by invitation NCT04885959 - The Effects of Traditional Asian Diet on Gut Microbiome and Metabolome in Healthy Volunteers and Pregnancy on Subsequent Infant's Allergy Development N/A
Recruiting NCT03974555 - Epidemiological Investigation and Cohort Study on Food Allergy in Children Aged 3 to 6 Years in Wenzhou and Taizhou Urban Areas
Recruiting NCT05177744 - Toxicity of Micro and Nano Plastics Combined With Environmental Contaminants on the Risk of Allergic Disease
Completed NCT01420705 - Bacille Calmette-Guérin (BCG) Vaccine and Atopy N/A
Completed NCT00850668 - Peanut Allergy Vaccine Study in Healthy and Peanut-allergic Adults Phase 1
Withdrawn NCT00736112 - Food Allergy - Tubes - Adenoids (FATA) Trial N/A
Active, not recruiting NCT00298337 - Use of Probiotic Bacteria in Prevention of Allergic Disease in Children 1999-2008 Phase 2/Phase 3
Completed NCT03693456 - Food Allergy Diagnostic Test Response to Previous Oral Challenge Response N/A
Completed NCT00461097 - Oral Immunotherapy for Childhood Egg Allergy Phase 2
Completed NCT02606721 - Food Allergy Challenge Diagnostic Study
Active, not recruiting NCT02457416 - Take Away Food Allergy; Inducing Tolerance in Children Allergic to Peanut N/A
Completed NCT02825069 - Study on the Induction of Food Tolerance in Babies N/A
Completed NCT01084174 - A Randomized, Double-Blind, Placebo-Controlled Pilot Study of Sublingual/Oral Immunotherapy for the Treatment of Peanut Allergy Phase 1/Phase 2
Completed NCT00597675 - Oral Immunotherapy for Peanut Allergy (PMIT) Phase 2
Completed NCT00932828 - Determining the Efficacy and Value of Immunotherapy on the Likelihood of Peanut Tolerance: The DEVIL Study Phase 2
Completed NCT01373242 - Sublingual Immunotherapy for Peanut Allergy and Induction of Tolerance Phase 1/Phase 2
Completed NCT00578656 - An Interventional Study of Milk Allergy Phase 0
Completed NCT00356174 - An Observational Study of Childhood Food Allergy N/A
Terminated NCT02213341 - Impact of Vaccination on Th2 Immunity in Infancy