Food-Drug Interactions Clinical Trial
Official title:
Phase 1 Study of the Hemodynamic and Pharmacokinetic Interactions Between Coffee and Felodipine
Coffee is a globally popular beverage. More than half of the United States population spends
an estimated $ 40 billion on the purchase of coffee each year. Personal consumption habits
can vary. For example, the frequency of ingestion ranged from 59% for every day to 8% for
less than one day per week consumption in one survey. In the case of occasional consumption,
coffee can markedly elevate blood pressure in normotensive and hypertensive individuals. This
pressor effect can occur with a caffeine dose of 200 - 250 mg, which can be found 2 - 3 cups
of coffee. A major active constituent in coffee is caffeine, which is the most widely used
pharmacological substance in the world.
Drug therapy plays a major role in the management of hypertension. However, the interaction
between coffee or caffeine and blood pressure lowering drugs has been assessed in only three
clinical studies that were reported more than three decades ago.
We conducted a comprehensive interaction study involving a commonly ingested amount of a
particular Colombian coffee and felodipine in healthy middle-aged men and women. Peripheral
(brachial) and central (aortic) hemodynamics and caffeine and felodipine pharmacokinetics
were evaluated.
n/a
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT02848430 -
Hop Botanical Dietary Supplements - Metabolism and Safety in Women
|
N/A |