Clinical Trials Logo

Clinical Trial Summary

Early and regular ingestion of the common allergens, peanut and egg has been shown to be an effective allergy prevention strategy. It is not clear whether this is also true of tree nut allergy. Current practice in many Australian allergy clinics for children with peanut allergy (high risk of tree nut allergy), is to advise families to introduce each individual tree nut into their child's diet via a cautious home introduction protocol without prior allergy testing (screening). The safety and effectiveness of an early and regular ingestion strategy for the prevention of tree nut allergy has not been formally evaluated and it is known that around a third of children with peanut allergy develop one or more other nut allergies. This trial is a 2-armed, open-label, randomized, controlled trial (RCT) to assess the safety and efficacy of a supervised hospital based multi-tree nut (almond, cashew, hazelnut and walnut) oral food challenge (OFC) + then home introduction of the remaining tree nuts versus standard care (home introduction of all 8 tree nuts) in infants with peanut allergy to reduce the risk of developing tree nut allergy.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT04801823
Study type Interventional
Source Murdoch Childrens Research Institute
Contact
Status Active, not recruiting
Phase Phase 3
Start date June 1, 2021
Completion date August 2024

See also
  Status Clinical Trial Phase
Not yet recruiting NCT06260956 - Expecting Mother's Study of Consumption or Avoidance of Peanut and Egg N/A
Recruiting NCT05965063 - The Role of Bifidobacterium Intervention in Food Allergic Infants N/A
Completed NCT04851340 - Investigating the Detection of Bovine and Soy Proteins in Human Milk N/A
Enrolling by invitation NCT04604431 - Intervention to Reduce Early (Peanut) Allergy in Children N/A
Completed NCT04651829 - Suspicion of Non IgE-mediated Cow's Milk Protein Allergy: Prevalence and Evolution
Not yet recruiting NCT06262867 - Early Allergen System Experience N/A
Enrolling by invitation NCT05287074 - The Significance of a Timely Food Allergy Diagnosis and Optimal Surveillance of Nutritional Status in Children
Enrolling by invitation NCT04955132 - Impact of E-learning on Parental Confidence in Managing Food Allergy N/A
Recruiting NCT03309488 - Basophil Activation Test to Diagnose Food Allergy
Active, not recruiting NCT04017520 - Breast Milk: Influence of the Micro-transcriptome Profile on Atopy in Children Over Time
Recruiting NCT05309772 - The Clinical Impact of the Basophil Activation Test to Diagnose Food Allergy N/A
Completed NCT05215080 - The Tolerance of Organic Formula Milk and Its Fecal Microbiome Characteristic in Infants N/A
Recruiting NCT04653324 - A Registry for the Food Allergy Community
Recruiting NCT06273605 - The Egg Up Trial - Testing a New Treatment Pathway for Infants With Newly Diagnosed Egg Allergy N/A