Fontan Palliation Clinical Trial
Official title:
Study of Upright Versus Supine Exercise Testing in Fontan-palliated Patients, Compared With Healthy Controls, to Evaluate for Postural Effects on Exercise Parameters
Fontan-palliated patients comprise an interesting group of single-ventricle patients who are
dependent upon passive return of blood from the body to the lungs. Systemic venous pressures
are therefore quite elevated, and one study demonstrated that venous capacitance was
diminished. In addition, these patients have markedly diminished aerobic capacity (Max VO2).
Although one recent study demonstrated that Fontan patients can increase their Max VO2
through diligent cardiac rehabilitation, their ultimate results were still well below
average.
It has previously been described that normal, healthy subjects have decreased exercise
performance in a supine vs upright position. However, due to high venous pressures and the
need for systemic venous return to overcome gravity in order to perfuse the lungs, one might
hypothesize that Fontan patients would have increased exercise performance in a supine vs
upright position. The investigators are interested in studying this hypothesis.
n/a
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Recruiting |
NCT05206955 -
Study of Tadalafil vs. Placebo for Improving Hemodynamics and End-Organ Dysfunction in Fontan Physiology
|
Phase 3 | |
| Enrolling by invitation |
NCT02659462 -
Cardio Pulmonary Exercise Testing in Patients Post the Fontan Palliation in Comparison With Patients With Repaired Congenital Heart Disease and Healthy Volunteers.
|
N/A |