Follicular Lymphoma Clinical Trial
Official title:
CD180 Overexpression in Follicular Lymphoma Is Restricted to the Lymph Node Compartment
Background:Altered Toll-like receptor (TLR) expression levels and/or mutations in its
signaling pathway (such as MyD88 mutation) contribute to the pathogenesis of
lymphoproliferative disorders (LPD). CD180 is an orphan member of the TLR family that
modulates the signaling of several TLRs, but only limited studies have evaluated its
expression by flow cytometry (FCM) in LPD.
Methods: Using a multiparameter FCM approach, biologists have assessed CD180 mean
fluorescence intensity (MFI) in lymph nodes (LNs) and peripheral blood (PB) samples obtained
from patients with follicular lymphoma (FL; LN/PB, n=44/n=15), chronic lymphocytic leukemia
(CLL, n=26/n=21), mantle cell lymphoma (MCL, n=13/n=17), and marginal zone lymphoma (MZL,
n=16/n=12). Specimens from non-tumoral PB and LN (n=8/n=12) were used as controls.
n/a
Observational Model: Cohort, Time Perspective: Retrospective
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